摘要
蛋白质芯片技术日趋成熟,研究重点已由对整个蛋白质组的观察,转变为对具有重要功能的蛋白质的研究。低密度蛋白质芯片技术的建立为这一研究转变提供了有力工具,具有交叉影响小,信号强度高,结果准确性好的特点。文章综述了低密度蛋白质芯片在疾病诊断和监控,药物发现和检测,分子相互作用和信号通路等医药研究中的应用。
Protein biochips industry has been making significant progress recently. It played a role in the discovery-oriented proteomics, but now the research emphasis turns to the study of important functional proteins. The emergence of the low density protein biochip technique facilitated this study conversion. This technology has advantages of low cross-reaction, high signal intensity and good precision. This paper reviewed various medical and pharmaceutical applications of the low density protein ＂biochips in disease diagnostics and monitoring, drug discovery and testing, as well as molecular interaction and signaling pathways.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2006年第4期389-393,共5页
Chinese Pharmacological Bulletin
基金
国家高技术研究发展计划(863计划)资助项目
"微流体及兴奋剂检测芯片的研究和开发"(No2002AA2Z2004)
"创新药物筛选技术平台的研究和应用"(No2002AA2Z343B)
"人类重要生理活性及具有药物开发前景的功能基因研究"(No2002BA711A01-11)
关键词
蛋白质芯片
抗体
酶
蛋白质结合域
疾病诊断
药物发现
proteinprotein binding domain
biochip
antibody
enzyme
diagnosis
drug discovery
