摘要
目的:探讨复方丹参对门脉血流动力学的影响。方法:用四氯化碳(CCl4)复合致病因子复制60只Wistar大鼠肝硬化模型,将其中56只成功制模大鼠随机均分为4组:复方丹参3、10及15 d组以及对照组,分别给予复方丹参(5 mL.kg-1.d-1)3、10及15 d和同剂量生理盐水15 d。分别于给药结束后检测门静脉血流量、肠系膜上动脉血流量、门静脉压力、腹主动脉压。结果:与生理盐水对照组比较,复方丹参3、10及15 d组的门静脉压力、门静脉血流量、肠系膜上动脉血流量、腹主动脉压力均呈梯度性降低(P<0.05),复方丹参15d组较3 d组和10 d组上述指标下降明显(P<0.05),复方丹参3 d和10 d组,血流动力学指标变化差异无显著性(P>0.05)。结论:复方丹参能降低血流量和门静脉压力,并且延长丹参用药时间则更有效地降低血流量和门静脉压力。
Objective To investigate the effect of radix salviae milliorhize on hemodynamics of portal hypertensive rats. Methods 60 Wistar rat models with portal hypertension were induced by CCl4. Among them 56 rats with portal hypertension were divided at random into 4 groups., radix salviae 3 d group, radix salviae 10 d group, radix salviae 15 d group, and control group. After administration, the blood flow of vena portae, superior mesenteric artery, superior mesenteric artery and pressure of vena portae, average arterial pressure were measured. Results Compared with 0. 9% Natrii Chloridi control group, the blood flow of vena portae, superior mesenteric artery, superior mesenteric artery and pressure of vena portae, average artery pressure in radix salviae milliorrhize 3, 10 and 15 d groups were decreased significantly （P〈0.05）, but between radix salviae 3 d group and 10 d group, there were no significant differences （P〈0. 05）. Conclusion Radix salviae milliorhize can be employed for treating portal hypertension. Radix salviae milliorrhize can decrease the blood flow and portal pressure, moreover, the effect can be enhanced with the elongation of treatment time.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2006年第2期232-233,237,共3页
Journal of Jilin University：Medicine Edition
基金
国家自然科学基金资助课题(30070692)
关键词
丹参注射液
门脉高压
血流动力学
injection salviae miltiorrhiza
portal hypertension
hemodynamics
