摘要
目的观察不同时间90dB次声诱导的大鼠心肌细胞凋亡,并探讨其相关机制.方法用8Hz/90dB的次声分别作用大鼠1,7,14,21和28d,每日2h,观察大鼠心肌细胞凋亡率的变化,测定大鼠7心肌细胞钙离子浓度的变化.结果大鼠心肌细胞凋亡率随时间逐渐增大(P<0.01),大鼠心肌细胞内钙离子浓度随时间逐渐增多(P<0.01).结论90dB次声可引起大鼠心肌凋亡,与次声暴露时间有关.
AIM： To observe the changes of cardiac cell apoptosis in rats exposed to infrasound with 8 Hz of 90 dB for different time periods and to study its underlying mechanism. METHODS： The rats were exposed to infrasound with 8 Hz/90 dB 2 h daily for 1,7, 14, 21 and 28 d and then the cardiac cell apoptosis and the [ Ca^2 ＋ ] change in cardiac cells were measured. RESULTS： Cardiac cell apoptosis rate increased as time went on （P 〈0.01 ） and [ Ca^2＋ ] in cardiac cells significantly increased as time went by（P 〈0. 01）. CONCLUSION： The 90 dB infrasound can induce the cardiac cell apoptosis. These changes are positively associated with the infrasound exposure time.
出处
《第四军医大学学报》
CAS
北大核心
2006年第6期490-492,共3页
Journal of the Fourth Military Medical University
基金
国家自然科学基金资助(30400091)
关键词
次声
大鼠
心肌
细胞凋亡
钙
infrasound
rats
myocardium
apoptosis
calcium
