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胆碱酯酶结构与功能及磷酰化酶重活化机理 被引量:10

Progress in the Studies of Structures and Functions of Acetylcholinesterase and the Reactivation Mechanism of Organophosphate-inhibited Enzyme.
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摘要 对近几年来应用计算机模拟和分子生物学定点突变技术研究乙酰胆碱酯酶的结构与功能关系的进展进行了综述,对不同抑制剂的抑制作用机理及重活化药物对不可逆抑制剂有机磷酸酯磷酰化酶的重活化作用机理研究进展也进行了综述. After the elucidation of the threedimensional structure of Torpedo acetylcholinesterase by X-ray diffraction in 1991,studies by computer modelling and site-directed mutagenesis have led to significant progress in the elucidation of the structure-function relationship of this enzyme. And based upon this,efforts have been made to invcstigale further mechanism of inhibition by irreversible inhibilors (organophosphate), and that of the reactivation of the irreversiblly inhibited enzyme. In addition, progress in study of aging if,echanlsm of the inhibited enzyme was also reviewaed.
作者 罗春元
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 1996年第4期329-333,355,共6页 Progress In Biochemistry and Biophysics
关键词 乙酰胆碱酯酶 磷酰化酶 重活化机理 acetycholinesterase organic phosPhate phosphorylated enzyme reactivation mechanism
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参考文献2

  • 1李松,生物化学与生物物理学报,1995年,27卷,423页
  • 2Qian N Q,FEBS,1993年,336卷,263页

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