摘要
【目的】探讨直肠癌根治术后经门静脉灌注化疗药物预防大肠癌肝转移的临床疗效。【方法】采用严格随机对照前瞻性研究设计,对50例Dukes A、B和C期行大肠癌根治术的患者予以门静脉插管5氟尿嘧啶化疗,并以同期50例Dukes A、B和C期行单纯大肠癌根治术患者作对照。观察两组术后转移及生存情况。【结果】治疗组术后肝转移率34.0%(17/50),1、3、5年和10年生存率分别为95.61%、82.21%、73.89%和25.16%;对照组术后肝转移率72.0%(36/50),1、3、5年和10年生存率分别为92.28%、79.91%、52.16%和13.11%,两组5年和10年生存率相比较差异有显著性(P<0.01)。其中两组Dukes A和B期,术后生存率相比较差异无显著性(P>0.05)。【结论】对大肠癌患者行根治性切除的同时予以门静脉化疗可有效降低肝转移发生率,延长患者5年和10年生存率,提高患者生活质量。
[objective]To explore clinical therapeutic effects of regional chemotherapy by portal vein infusion to prevent hepatic metastasis after resection of colon cancer. [Methods]After radical resection, 100 patients of Dukes A, B and C with colon cancer were randomly divided into two groups： 50 cases were treated by radical resection combined 5-FU regional chemotherapy by portal vein infusion： 50 cases were treated by radical resection only for contrast in the same time. Hepatic metastasis and survival time were observed. [Results] The rate of hepatic metastasis in the treated group was 34.0%（17/50）, and the 1, 3, 5-and 10-year survival rates were 95.61%, 82.21%, 73.89% and 25.11%, respectively. The rate of hepatic metastasis in the control group was 72.0%（36/50）, and the 1, 3, 5-and 10 year survival rates were 92.28%, 79.91%, 52.16% and 13.11%. There were significantly differences in 5 and 10-year Survival rates （ P 〈0.01）. There were not significant differences about survival rates in stage Dukes A and B （P 〉0. 05）. [Conclusion]Regional chemotherapy by portal vein infusion after resection of colon cancer can decrease the hepatic metastasis rate, and raise the 5- and 10-year survival rate. Thus it improves the patients quality of life.
出处
《医学临床研究》
CAS
2006年第1期30-31,35,共3页
Journal of Clinical Research
