摘要
【目的】探讨托瑞米芬(TOR)对男性乳腺发育症的疗效。【方法】65例病人随机分成两组,治疗组32例采用托瑞米芬治疗,对照组33例采用他莫昔芬(TAM)治疗,疗程均为2个月。【结果】治疗组32例中显效10例(31.3%),有效7例(21.8%),治愈13例(40.6%),总有效率93.8%,无效2例(6.2%)。不良反应较少,主要为消化道症状。对照组33例中显效5例(15.2%),有效14例(42.4%),治愈6例(18.2%),总有效率(75.8%),无效8例(24.2%)。治疗组中有并发症者9例(28.1%),对照组中有并发症者18例(54.5%)。【结论】托瑞米芬治疗男性乳腺发育症有较好疗效,副作用较轻,应用较安全。
[Objective]To study the effects of toremifene（TOR） on the treatment of gy：naecomastia. [Methods]Sixty-five patients with gynaecomastia were randomly divided to receive either 40 mg/d toremifene orally, or 20 mg/d tamoxifen （TAM）orally. The therapeutic courses were two months. [Results]Ten cases （31.3%） among 32 cases who received TOR demonstrated to be responsive, 7 cases （21.8%） showed to be effective, 13 cases （40.6%） showed to be cured. Total effective rate was 93.8%, 2 cases （6.2%） were not responsive. Main side effects were digestive tract symptom . Five patients （15.2%） among 33 patients who received TAM demonstrated to be responsive, 14 cases （42.4%） showed to be effective, 6 cases （18.2%） showed to be cured, Total effective rate was 75.8%, 8 patients were not responsive （24.2%）, 9 cases （28. 1% ） of 32 cases received TOR with side effects, while 18 patients （54.5 % ） of 33 patients received TAM with side effects. [Conclusion]TOR has better effects on the treatment of gynaecomastia than TAM. It has less side effect and better safety on clinical application than TAM.
出处
《医学临床研究》
CAS
2006年第3期383-384,共2页
Journal of Clinical Research
