摘要
目的了解转化生长因子-β1(TGF-β1)与哮喘的相关性及川芎嗪治疗哮喘的研究现状。方法应用现代信息技术,通过互联网等,查阅近年来国内外相关资料并进行分析、整理、总结,对TGF-β的生物学特征、TGF-β1与哮喘发病机制的相关性、川芎嗪对哮喘的治疗及其与TGF-β1的关系进行综述。结果TGF-β1在哮喘发病中起到复杂的生物调节作用,动物实验显示,川芎嗪治疗哮喘有效,而且部分是通过抑制TGF-β1的表达起作用。结论深入研究TGF-β1、哮喘及川芎嗪之间的相关性,会为哮喘的临床分级和治疗提供新的思路。
Objective To elucidate correlation of transforming growth factor β1 （TGF-β1）and asthma and advances on treatment of ligustrazine on asthma. Methods By modern information technology such as Internet, Domestic and foreign related literatures were analyzed, summarized. The biological characteristic of TGF- β1, correlation of TGF - β1 with pathogenesis of asthma and treatment of ligustrazine on asthma and relation of ligustrazine and TGF -β1 were reviewed. Results TGF -β1 played a very implicated biological regulation on development of asthama, Animal experiments indicated that lignstrazine was effective in treatment of asthma, moreover, in part exerted role by inhibiting expression of TGF- β1. Conclusion Thorough study of TGF -β1 and correlation of asthma and lignstrazine will provide a new perspective for clinical grading and treatment of asthma.
出处
《新乡医学院学报》
CAS
2006年第2期207-209,共3页
Journal of Xinxiang Medical University
关键词
转化生长因子β`
哮喘
川芎嗪
transforming growth factor -β1
asthma
ligustrazine
