摘要
目的调查医院内感染铜绿假单胞菌(PA)的现状及耐药性情况,为临床提供抗菌药物治疗对策。方法抽取医院内感染PA的病例,分别对临床感染状况,细菌耐药性,抗菌药物使用情况进行回顾性调查。结果204株医院内感染PA对18种抗菌药物的平均耐药率达45.26%,其中47株产AmpC酶,31株产ESBLs酶,7株产AmpC酶和ESBLs酶,产酶菌株达38.24%,产酶菌与广谱抗菌药物在临床的广泛使用密切相关。结论医院感染PA的耐药情况十分严峻,加强细菌培养和药敏监测,及时从经验治疗改为针对菌种治疗,选择敏感性强的药物,避免广谱抗菌药物的长期应用,才能减少抗菌药物的选择压力。
Objective To study the present situation of nosocomial infection of Pseudomonas aeruginosa （PA） and the drug resistance of the bacteria to antibiotics so as to provide tactics for the rational use of antibiotics in the clinical treatment of PA infection. Methods A retrospective survey was carried out by reviewing the case histories of patients with nosocomial PA infections in our hospital with respect to the status of PA infection inside the hospital, resistance of the bacteria to drugs as well as the application of antibiotics. Results The average rate of drag resistance of the 204 strains of PA isolated from patients with nosocomial infections of the bacteria to 18 antibiotics was up to 45.26 %. Among these, 47strains produced AmpCβ- lactamase , 31 produced ESBLSs and 7 produced both AmpC β-lactamases and ESBLSs, the rate of enzyme-producing PA totaling 38.24 %. The appearance of these enzyme-producing PA was shown to be closely related to the extensive application of broad-spectrum antibiotics. Conclusion The situation of drug resistance of PA during nosocomial infection of the bacteria was shown to be extremely rigorous. The pressure of the choice of antibiotics could be eased only by energetic bacteria culture and drug sensitivity tests, timely switching from empirical to targeted treatment, the use of drugs to which the bacteria are highly sensitive as well as refrainment from long-term application of broad-spectrum antibiotics.
出处
《医药导报》
CAS
2006年第4期359-361,共3页
Herald of Medicine
关键词
铜绿假单胞菌
感染
医院
耐药性
Pseudomonas aemginosa（PA）
Nosocomial infection
Drug resistance
