摘要
目的探讨伊贝沙坦对老年原发性高血压患者逆转左心室重构的保护作用。方法将52例经过洗脱期的老年原发性高血压患者随机分为伊贝沙坦组和安慰剂组,治疗8周。用药前、治疗中、用药后分别行偶测血压、动态血压、超声心动图测定,观察并比较治疗前后、两组偶测血压、动态血压、左房内径(LA)、左室舒张末期内径(LVDd)、舒张期室间隔厚度(IVSd)、左室后壁厚度(LVPW d)、E/A比值和左室重指数(LVM I)水平的变化。结果(1)偶测血压:治疗组SBP由(152±13)mmHg下降至(130±10)mmHg(P<0.05),DBP由(96±8)mmHg下降至(78±6)mmHg(P<0.01);对照组SBP由(148±13)mmHg下降至(145±10)mmHg(P>0.05),DBP由(97±8)mmHg上升至(98±6)mmHg。两组降压幅度相比较,P<0.01;(2)治疗组动态血压检测:患者24 h平均收缩压和24 h平均舒张压均降低(P<0.05),不仅白昼dSBP、dDBP,而且夜间nSBP、nDBP也明显降低(P<0.05);(3)超声心动图检测:治疗组IVSd、LVPW d、LVM I显著下降(P<0.05),E/A比值显著提高(P<0.05);对照组患者各项指标无统计学差异(P>0.05),两组相比较,IVSd、LVPW d、LVM I差异有显著性(P<0.05),LA差异有极显著性(P<0.01)。结论伊贝沙坦对老年原发性高血压患者在有效降压的同时,可逆转左心室重构,且不良作用小。
Aim To observe the antihypertensive effect of irbesartan and its effect on reversing left ventricular remodelling in elderly patients with essential hypertension （EH）. Methods Fifty-two elderly patients with mild to moderate EH were randomly divided into two groups. The patients in treatment group took 150 mg of irbesartan once a day,and the patients in control group took placebo once a day. Efficacy was evaluated 8 weeks after treatment compared with echocardiography. Results Compared with that before treatment,the antihypertensive effect were significant in 24 h SBP, dSBP, nSBP （ P 〈 0. 05 ）, 24 hDBP, dDBP and nDBP （ P 〈 0. 01 ） in treatment group as well as significantly reduced in IVSd, LVPWd, LVMI （ P 〈 0.05 ） and significantly increased in E/A （ P 〈 0.05 ）. There were significant difference between two groups in antihypertensive effect and reversing left ventricular remodelling （ P 〈0. 05 or P 〈0.01 ）. Conclusion Our results showed Irbesartan had the effect on antihypertension and reversion of left ventricular remodeling to geratic essential hypertension with little side effects.
出处
《安徽医药》
CAS
2006年第3期176-177,共2页
Anhui Medical and Pharmaceutical Journal
关键词
老年原发性高血压
伊贝沙坦
左心室重构
geratic essential hypertension
irbesartan
left ventricular remodelling
