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环孢素和苯妥因治疗药物监测内部质控的连续性评价 被引量:1

Successive Assessment of Internal Quality Control for Therapeutic Drug Monitoring of Cyclosporine and Phenytoin
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摘要 目的:及时发现测定误差成因,确保血药浓度监测质量。方法:分析环孢素和苯妥因内部质量控制原始数据的分布和变化趋势,根据统计学原理判断测定误差的性质和来源。结果:被调查项目测定结果大于或小于靶值的数据分布明显失衡,具有极显著性或显著性差异(P<0.01或P<0.05)。结论:某些实验室测定准确性较差,除与随机误差有关外,还与系统误差有关。 OBJECTIVE: To discover early the latency factors influencing assay accuracy and to improve the quality of therapeutic drug monitoring (TDM). METHODS: The distribution and changing trend in the original data of internal quality control (IQC) for cyclosporine and phenytoin were analyzed, and the property and source of determination errors were estimated according to the statistical theory. RESULTS: The determined data which were more or less than target values were evidently out of balance in distribution, which showed greatly significant or significant difference(P 〈 0.01 or P 〈 0.05).CONCLUSION : Low accuracy in laboratory assay is not only related to random errors but also to system errors.
作者 储小曼
出处 《中国药房》 CAS CSCD 北大核心 2006年第6期440-442,共3页 China Pharmacy
关键词 治疗药物监测 室内质量控制 连续性评价 环孢素 苯妥因 Therapeutic drug monitoring Internal quality control Successive assessment Cyclosporine Phenytoin
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