摘要
目的检测CD34在膀胱移行细胞癌组织中的表达及微血管密度(MVD),探讨其在膀胱移行细胞癌发生、发展、浸润和转移中的作用及相互关系。方法采用免疫组织化学SP法。结果CD34蛋白在膀胱移行细胞癌无淋巴结转移组和淋巴结转移组中的阳性表达率分别为55.00%和40.00%,MVD值分别为26±6,24±5。两组间CD34蛋白阳性表达率及MVD值分别比较,差异均有统计学意义(P<0.05)。无明显浸润组和浸润组中CD34蛋白的阳性表达率分别为:57.89%和35.29%,MVD值分别为29±5,25±7。两组间CD34蛋白阳性表达率及MVD值分别比较,差异均有统计学意义(P<0.05)。结论CD34蛋白阳性表达及MVD值的高低与膀胱移行细胞癌发生、发展、浸润和转移有关。
Objective To detect the expression of CD34 and MVD and discuss their con＇elation of the pathogenesis,development, invasion and metastasis in transitional cell carcinoma of the bladder tissues. Methods By adopting immunohistochemisty SP method. Results In the groups of non - lymphaden metastasis and lymphaden metastasis, the positive rates of CD34 protein were 55.00% （11/20 ） and 40.00% （4/10）respectively and the MDV were 26 ± 6 and 24 ± 5 respectively. The difference of them in the two groups had statistical significance（ P 〈 0.05 ）. In the groups of non - invasion and invasion, the positive at of CD34 protein were 57.89% （11/19） and 35.29% （6/17） respectively and the MDV were 29 ± 5 and 25 ± 7 respectively. The difference of them in the two groups had statistical significance （ P 〈 0.05 ）. Conclusion The positive expression of CD34 and MVD were correlated with pathogenesis,development, invasion and metastasis of transitional cell carcinoma of the bladder.
出处
《中原医刊》
2006年第6期6-9,共4页
Central Plains Medical Journal
关键词
膀胱移行细胞癌
CD34
MVD
转移
Transitional cell carcinoma of the bladder
CD34
MVD
Metastasis
