摘要
颞颌关节（ＴＭＪ）骨关节病（ＯＡ）是口腔颌面外科的常见疾病，其发病机理不清，疗效不佳。作者对３６例不同程度ＴＭＪＯＡ患者关节滑液中细胞因子ＩＬ－１、ＩＬ－６活性的检测分析，从细胞及分子水平探讨ＴＭＪＯＡ的发病机理。结果表明：细胞因子ＩＬ－１、ＩＬ－６活性，随ＯＡ病变加重而升高（Ｐ＜０．０００１），且ＩＬ－１与ＩＬ－６呈正的直线相关关系（Ｐ＜０．００１）。本文从基质金属蛋白酶（ＭＭＰｓ）与其特异抑制物ＴＩＭＰｓ之间的平衡关系，以及细胞因子的调控机理等方面，探讨了ＴＭＪＯＡ的发病机理及未来的研究方向。
TMJ osteoarthrosis (OA) is frequently seen in the Oral and Maxillofacial Surgery clinics. In order to investigate cellular and molecular basis of the pathogenesis of TMJOA,the levels of IL-1 and IL-6 in synovial aspirates from different stages of TMJOA patients were determined and analysed. It was found that both of them were highly correlated with the severity of TMJOA (p<0. 0001). A positive linear correlation was also found between IL-1 and IL-6 (p <0. 0001). The balance and imbalance between MMPs and TIMPs and the modulatory mechanism of cytokines were introduced and their possible roles in the pathogenesis of TMJOA were discussed.
出处
《上海口腔医学》
CAS
CSCD
1996年第1期19-21,24,共4页
Shanghai Journal of Stomatology
基金
国家自然科学基金
国家教委博士学科点科研基金
