摘要
应用ＣＨＯＰ和ＣＨＶＰ两组方案治疗５５例非何杰金淋巴瘤（ＮＨＬ），两组方案的有效率分别为８１．８％及９０．９％，ＣＲ率为３６．４％及４０．９％。结果显示，两方案有效率及ＣＲ率差异无显著性（Ｐ＞０．１０）。在毒副作用的观察中发现，ＣＨＶＰ比ＣＨＯＰ方案有较重的骨髓抑制作用（Ｐ＜０．０２５～０．００５）。认为，为避免过早的骨髓抑制，对非何杰金淋巴瘤的Ⅱ期病人可首选ＣＨＯＰ方案，而对Ⅲ、Ⅳ期病人或复发病人，两组方案可任选一种，或在ＣＨＯＰ失败后可改用ＣＨＶＰ方案。
Fifty-five patients with Non-Hodgkin’s lymphoma(NHL) were treated with CHOP and CHVPregimens in comparison.The responsive rates of CHOP and CHVP were 81.8%and 90.9%,the CR rateswere 36.4%and 40.9%respectively.No statistical difference could be seen (P > 0.10). However,theCHVP was stonger in myelosuppression than the CHOP (P < 0. 025～0. 005).In order to avoid earlymyelosLippression,CHOP is,therefore,the regimen of first choice in treating patients with NHL in Ⅱstage,As for treating patients inⅢ～Ⅲ stage,either of the two regimens can be used,or the CHVP is usedwhen the CHOP fails.
出处
《蚌埠医学院学报》
CAS
1996年第3期166-168,共3页
Journal of Bengbu Medical College
