摘要
目的优选定喘宁贴剂的基质组成比例。方法选用甘油、单甘酯、石蜡、凡士林的用量配比为因素,在三个水平上,以贴剂的熔化性、粘性、均匀度和硬度为指标,用L9(34)表进行实验。结果以A1B2C2D1为优选基质组成,即甘油0.5g、单甘酯1g、石蜡1 g、凡士林0.5 g。结论最佳的基质比例所制备的定喘宁贴剂稳定性良好。
Objective： To optiraizate matrix composition for patch of cough and asthnm Methods. According to the target that affect the ability of emulsion＇ s meltability, well-distribution, viscosity and solidness, we select the using rartio of glycerin, paraffin wax, glyceryl monostearate and Vaseline as factors, and then design the orthogonal table 1.9 （34） for experiment, Results： The optimum matrix composition was glycerin 0. 5g, glyceryl monostearate lg, paraffin wax Ig and vaseline 0. 5g. Conclusion： According to the optimum protion of matrix, patch of cough and asthma will have great stability.
出处
《湖北中医学院学报》
2006年第1期41-42,共2页
Journal of Hubei College of Traditional Chinese Medicine
基金
湖北省科技厅资助项目
[2003A302B02]
关键词
正交试验法
基质制备
物理稳定性
Orthogonal design Method, matrix composition, Physical stability
