摘要
评价国产ｃｌａｒｉｔｈｒｏｍｙｃｉｎ（ＣＲＭ）对临床分离到的４６４株致病菌的体外抗菌作用，并与红霉素（ＥＭ）、麦迪霉素（ＭＤＭ）、麦白霉素（ＭＬＭ）、柱晶白霉素（吉他霉素，ＬＵＭ）进行比较。结果表明ＣＲＭ对ＥＭ敏感的金葡球菌、表葡球菌、肺炎链球菌和化脓链球菌的抗菌作用优于ＥＭ，明显优于其它３种同类对照药，ＭＩＣ（９０）为０．０６２～２ｍｇ／Ｌ；对部分ＥＭ耐药的表葡球茵，化脓链球菌和粪链球菌也有一定的抗菌作用；对流感嗜血杆菌和对ＥＭ敏感的粪链球菌的抗菌作用同ＥＭ，优于其它３种同类对照药，ＭＩＣ_（９０）为０．５～２ｍｇ／Ｌ；对部分厌氧菌也有一定的抗菌作用，细菌接种量对ＣＲＭ的抗菌作用有一定的影响，但仍在敏感范围之中；ｐＨ值的变化影响ＣＲＭ抗菌作用，其抗菌作用在碱性条件下较强，尤以ｐＨ８．５时为显著；少量的人血清不影响ＣＲＭ的抗菌作用，但浓度加至７５％，ＣＲＭ的抗菌作用减弱。
The in vitro activities of clarithromycin compared with erythromycin and other 3 macrolides against 464 clinical isolates were studied.Results indicated that the in vitro activity of clarithromycin against erythromycin-sensitive Staph.Spp.and Strep.spp.(MIC(90) 0.062～2mg/L)was more active than that of erythromycin and other 3 macrolides.For some anerobics and some erythromycin-resistant Staph.spp and Strep. spp.clarithromycin also showed good antibacterial activities.Against H.influenza and erythromycin-sensitive Strep,faecalis, the activity of clarithromycin with MIC(90)0.5～2mg/L was similar to that of erythromycin and stronger than that of 3 other macrolides.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1996年第3期205-209,共5页
Chinese Journal of Antibiotics
