摘要
采用彗星试验和微核试验,协同探索了五氯酚钠(Na-PCP)、二(口恶)(口英)类物质联合作用对血吸虫病流行区和正常生活区的人体外周血淋巴细胞影响效应.结果表明,实际用药区居民的外周血淋巴细胞以及用五氯酚钠与二(口恶)(口英)类物质联合作用处理过的正常人外周血淋巴细胞,其彗星率与微核率均高于对照组,在一定浓度范围内有剂量效应关系;基本的联合毒性作用推测为Na-PCP中的杂质PCDs与PCDFs等多种化学物质会损伤人体外周血淋巴细胞的DNA,其毒性作用比单一的二(口恶)(口英)类物质作用强.
Adopting comet test and micronucleus test, the influence effect of sodium pentachlorophenate （Na-PCP） united role with dioxins on the lymphocyte of human peripheral blood in schistosomiasis epidemic area and normal living area was explored corporately. The comet rate and micronucleus rate of peripheral blood lymphocyte of residents in taking actually medicine area and these rates of the lymphocyte of the normal person treated with the united of Na-PCP and dioxins were higher than those in control group, and it have dose-effect relationship in definite concentration range. The basic united toxic role might be that PCDDs and PCDFs in Na-PCP could damage the DNA of lymphocyte of human peripheral blood, of which the toxic role was stronger than that of single dioxins.
出处
《中国环境科学》
EI
CAS
CSCD
北大核心
2006年第1期39-42,共4页
China Environmental Science
基金
国家"973"项目(2003CB415003)
国家自然科学基金资助项目(40332033)
关键词
五氯酚钠
二噁英
彗星试验
微核试验
淋巴细胞
sodium pentachlorophenate （Na-PCP）
dioxins
comet test
micronucleus test
lymphocyte
