摘要
目的:应用赭曲霉羟化酶系统对坎利酮进行生物转化,合成其羟基化衍生物。方法:应用赭曲霉对坎利酮进行生物转化,获得一个硫酸显红色的产物SIPI-CANR。结果:确定SIPI-CANR化合物结构为15-羟基坎利酮。结论:赭曲霉羟化酶系统对坎利酮进行生物转化,能够合成15-羟基坎利酮,其为一新化合物。
AIM： To synthesize hydroxylated derivatives of canrenone using Aspergillus ochraceus hydroxylation enzyme system by microbial transformation. METHOD： A red compound named as SIPI-CANR was obtained by bio-transforming canrenone using Aspergillus ochraceus;the purified SIPI-CANR was elucidated by spectral analysis. RESULT： The chemical structure of SIPI-CANR was elucidated to be 15-hydroxycanrenone, CONCLUSION： 15-Hydroxycanrenone can be synthesized by Aspergillus ochraceus hydroxylation enzyme system, and it is a new compound.
出处
《中国天然药物》
SCIE
CAS
CSCD
2006年第2期144-145,共2页
关键词
赭曲霉
坎利酮
15-羟基坎利酮
微生物转化
Aspergillus ochraceus
Canrenone
15-Hydroxycanrenone
Microbial transformation
