摘要
AIM： To investigate the effects of long-term albumin administration on survival, recurrence of ascites and onset of other complications. METHODS： One hundred consecutive patients admitted for first-onset ascites were randomized to receive diuretics plus human albumin 25 g/wk in the first year and 25 g every two wk thereafter （group 1） or diuretics alone （group 2）. The primary endpoint was survival without liver transplantation. Secondary endpoints were recurrence of ascites and occurrence of other complications. RESULTS： Median follow-up was 84 （2-120） mo. Albu- min-treated patients had significantly greater cumulative survival rate （Breslow test= 7.05, P= 0.0078） and lower probability of ascites recurrence （51% versus 94%, P〈0.0001）. Chronic albumin infusion resulted in a mean increase in survival of 16 mo. CONCLUSION： Long-term albumin administration after first-onset ascites significantly improves patients＇ survival and decreases the risk of ascites recurrence.
瞄准：在幸存上调查长期的白朊管理的效果，腹水的复发和另外的复杂并发症的发作。方法：为第一发作的腹水招收的 100 个连续病人被使随机化加人的白朊收到利尿剂第一年和 25 g 里的 25 g/wk 每二 wk 此后(组 1 ) 或利尿剂独自一个(组 2 ) 。没有肝移植，主要端点是幸存。第二等的端点是腹水的复发和另外的复杂并发症的出现。结果：中部的后续是 84 (2-120 ) 瞬间。对待白朊的病人有显著地更大的累积幸存率(Breslow test=7.05， P=0.0078 ) 并且腹水复发的更低的概率(51% 对 94% ， P<0.0001 ) 。长期的白朊注入导致了 16 瞬间的幸存的吝啬的增加。结论：在第一发作的腹水以后的长期的白朊管理显著地改进病人的幸存并且减少腹水复发的风险。
基金
Supported by grants from the Italian Ministry of Education, University and Research and the University of Florence, Italy
