摘要
采用柱层析法分离提纯栀子甙,选用食品级、药用级、分析纯的固定相和流动相,优化技术参数,达到了满意的分离效果。使用多元溶剂结晶栀子甙,得到白色针状晶体。该工艺得率高、效果好,可以实现工业化生产。所用的试剂安全无毒,得到的产品的纯度高、品质优,符合GMP、药品注册管理办法和中国药典2005版的要求,可作为食品添加剂中间体和单体药原料使用。
In order to purity and separate Geniposidc adopt column chromatography, select solid phase and fluent phase of good grade, medicine grade, analysis pure grade, optimize the technics data, obtain satisfaetional separated effect. Use the multi-solvent for crystallizing Geniposide, obtain white needle crystal, and crystal Geniposide monomer is eomfirmed the yield of this method is high, The cost is low, The effect is good. It is probable for industrieal production. Use solvent and reagent is innocuity safety. Quality and purity of obtained product is good. Accord standard of GMP medicine registration administer method and 2000 Edition China pharmacopoeia, It may be used in the food additive and material of medicine.
出处
《中国食品添加剂》
CAS
2006年第2期54-56,共3页
China Food Additives
基金
武汉重点科技攻关项目
编号:20056002050
关键词
栀子甙
结晶
柱层析
多元溶剂系统
geniposide
crystal
column chromatography
multi - soluent
