摘要
目的观察环磷酰胺（CTX）静脉冲击疗法治疗儿童频繁复发性肾病综合征的疗效及不良反应。方法选择171例频繁复发性肾病综全征患儿，均给予CTX静脉冲击治疗。具体方法：CTX8～12mg／（kg·d）加生理盐水或10％葡萄糖液100mL静滴，每日1次，连用2d，2周后再重复使用，共6～9次，总累积量平均150mg,／kg（120-180mg／kg）。同时口服泼尼松1．0mg／（kg·d）。结果治疗前后年复发次数中位数分别为6次和0次，治疗前后比较有显著性差异（P〈0．01）。治疗过程中除少数患儿出现胃肠道症状、白细胞总数降低厦个别惠儿GPT升高外，几无其他严重不良反应。结论CTX静脉冲击治疗儿童频繁复发性肾病综合征安全、有效。
Objective It is to observe the curative effect and untoward reaction of intravenous stosstherapy with Cyclophosphamide （CTX）on children with frequently relapsing nephritic syndrome. Methods 171 children with frequently relapsing nephritic syndrome were chosen and given intravenous stosstherapy with CTX. CTX was administered in a dose of 8-12 mg/（kg· d） on the first 2 days of two weeks and for 6- 9 times in all. Accumulated dose were 150 mg/kg averagely （120-180 mg/kg）. At the same time Prednisone was used by oral application in a dose of 1 .0 mg/（kg· d）. Results The median number of relapse times per year before and after therapy was 6 and 0 respectively. Compared with each other the difference was significantly （P 〈 0.01 ）. Except a few patients had gastrointestinal tract symptom, leucocytopenia and individual hepatic function＇s lesion, there were almost no serious untoward reaction. Conclusion Intravenous stosstherapy with CTX is a safe and effective method to treat children with frequently relapsing nephritic syndrome.
出处
《现代中西医结合杂志》
CAS
2006年第8期1000-1001,共2页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
儿童
环磷酰胺
肾病综合征
children
Cyclophosphamide
nephrotic syndrome
