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病毒性肝炎和肝硬化患者IL-6、TNF-α的变化 被引量:23

Determinations of IL-6 and TNF-α in patients with viral hepatitis and liver cirrhosis
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摘要 为研究白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)在肝炎和肝硬化(LC)患者中的作用。检测了15例正常人,18例急性病毒性肝炎(AH),37例慢性肝炎(CH),20例LC患者血清及外周血单个核细胞(PBMC)的IL-6、TNF-α水平。结果以CH患者IL-6、TNF-α水平最高(血清及PBMC的IL-6水平分别为72.1±32.94U/ml,140.7±33.5U/ml;血清及PBMC的TNF-α水平为3.97±1.38ng/ml,6.35±1.41ng/ml)。恢复期或稳定期TNF-α和IL-6水平明显低于急性期或活动期(P<0.01)。CH患者肝组织学活动指数(HAI)分数与PBMCIL-6和TNF-α水平呈正相关(γ分别为0.89,0.68;P<0.05)。提示IL-6和TNF-α是肝脏损害重要的炎症介质,介导肝细胞损害。 To investigate the possible immunopathogenic role of interleukin-6 (IL-6)and tu-mor necrosis factor-α in the liver damage,concentrations of IL-6 and TNF-αin the serum and PBMC were assayed in 15 normal subjects,18 patients with acute hepatitis(AH),37 with chronic liver dis-ease(CLD),and 20 with liver cirrhosis(LC).The results revealed that the levels of serum and PBMC IL-6、TNF-α were highest in patients with viral hepatitis,in particular those superinfected with hepatitis C and B. Hepatic histologic activity index(HAI)scores in patients with CLD were not correlated with serum IL-6 and TNF-α levels,but correlated with PBMC IL-6 and TNF-α levels.The above data suggested that the levels of PBMC TNF-α and IL-6 might reflect the severity of liver damage and IL-6 and TNF-α were very important rnediators of liver damage.The liver function im-proved with the declining of IL-6 and TNF-α both in serum and hepatic tissue. The abnormal eleva-tion of IL-6,TNF-α in serum and in hepatic tissue may lead to immunopathogenic reaction resulting in hepatocyte damage.
机构地区 沪州医学院附院
出处 《中华传染病杂志》 CAS CSCD 北大核心 1996年第3期144-147,共4页 Chinese Journal of Infectious Diseases
关键词 白细胞介素-6 肿瘤坏死因子-Α 病毒性肝炎 肝硬化 Interleukin-6 Tumor necrosis factor-αViral hepatitis Liver cirrhosis
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  • 1任红,中华内科杂志,1992年,31卷,334页

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