妍婷颗粒对输卵管炎性不孕大鼠模型ICAM-1的影响被引量：17

Influence of Yanting Granules on ICAM-1 in rat model of salpingitic infecundity

导出

摘要目的探讨中药妍婷颗粒对输卵管炎性不孕大鼠细胞间黏附分子-1(intercellular adhesion molecule,ICAM-1)的影响及其疗效与机理。方法用混合菌接种法制作输卵管炎性不孕大鼠模型,以妍婷颗粒进行治疗,分为灌肠和灌胃两组,治疗后用ELISA法检测血清中可溶性细胞间黏附分子-1(solubility intercellular adhesion molecule,sICAM-1)水平和用免疫组织化学方法检测大鼠ICAM-1蛋白表达。结果大鼠ICAM-1蛋白表达和血清中sICAM-1水平灌胃组与灌肠组均较模型组降低(P<0.05或P<0.01),且灌肠组较灌胃组亦低(P<0.05)。结论妍婷颗粒对大鼠ICAM-1蛋白表达和血清中sICAM-1水平有调节作用,从而对大鼠炎性不孕具有很好的治疗作用。 Objective To investigate the influence, curative effect and mechanism of Yanting Granules on intercellular adhesion molecule-1 （ICAM-1） in rat model of chronic salpingitic infecundity. Methods The rat model of chronic salpingitic infecundity was established by using mixed bacteria inoculation and then treated with Yanting Granules. The rats were divided into the coloclysis goup and oral group. After the treatment the serum level of solubility intercellular adhesion molecule-1 （sICAM-1） was detected with ELISA method and the ICAM-1 expression in rats was detected with immunohistochemistry. Result The serum level of sICAM-1 and ICAM-1 expression in rats in the coloclysis group and oral group decreased compared with that of the model group （P〈0.05 or P〈 0.01）. Those were lower in the coloclysis group than in the oral group （P〈0.05）. Conclusion Yanting Granules has an integrated ef- fect on the serum level of sICAM-I and ICAM-lexpression in rats and therapeutic effect on rat salpingitic infecundity.

作者杨新鸣侯丽辉吴效科

机构地区黑龙江中医药大学黑龙江中医药大学附属第一医院妇产科

出处《北京中医药大学学报（中医临床版）》 2006年第2期1-4,共4页 Journal of Beijing University of Traditional Chinese Medicine

基金黑龙江省科学技术厅攻关课题(No.GC01C142-02)

关键词输卵管炎性不孕妍婷颗粒细胞间黏附分子-1 蛋白表达可溶性细胞间黏附分子-1 salpingitic infecundity Yanting Granules intercellular adhesion molecule-1 expression solubility intercellular adhesion molecule-1

分类号 R271.14 [医药卫生—中医妇科学]

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参考文献2

1江占良,韩建国.过敏性鼻炎患者血清sICAM—1水平测定及其意义[J].山西临床医药,2000,9(11):867-868. 被引量：2
2王小梅,祝斌,徐军发,袁汉尧.溃疡性结肠炎患者C反应蛋白、炎性细胞因子和粘附分子水平的检测及其临床意义[J].广东医学院学报,2005,23(3):257-259. 被引量：10

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