摘要
目的探讨CA242和生存素(survivin)蛋白在胃癌中的表达及意义。方法应用免疫组织化学技术检测120例胃癌、30例异型增生和20例正常胃黏膜组织中CA242和survivin蛋白表达,并结合肿瘤的病理学行为和临床随访资料分析。结果在胃癌组织中,CA242和survivin阳性率分别为79.2%和75.8%,均显著高于异型增生和正常胃黏膜组织(P<0.05)。CA242和survivin表达与胃癌浆膜浸润、淋巴结转移和患者预后密切相关(P<0.05)。结论CA242和survivin表达与胃癌发生、转移和患者生存期有关,检测CA242和survivin蛋白表达可作为预测胃癌患者预后的参考指标。
Objective To investigate the expression of CA242 and survlvin protein in gastric cancer （GC） and its clinical significance. Methods Imounohistochemical staining was used to detect the expression of CA242 and survivin protein in 120 cases of GC,30 cases of gastric epithelial dysplasia and 20 cases of normal gastric mucosa. Pathological features of GC and clinical follow-up data were analysed. Results The positive rate of CA242 and survivin was 79.2 % and 75.8 %, respectively in primary GC. The positive rate of CA242 and survivin was higher in GC than in epithelial dysplasia and normal gastric mucosa （P 〈 0.05）. The expression of CA242 and survivin was closely related to infikration of serosa, metastasis of lymph node and prognosis of patients （P 〈 0.05）. Conclusion These data suggest that the expression of CA242 and survivin is closely related to carcinogenesis, metastasis and survival rate in GC. CA242 and survivin may be prognostic indicators of C,C.
出处
《山西医药杂志》
CAS
2006年第4期305-307,共3页
Shanxi Medical Journal
