摘要
以相转移催化法使２，３，４－三－Ｏ－乙酰基－１－溴－１－脱氧－α－Ｄ－葡萄糖醛酸甲酯与取代呋喃甲酸，取代苯甲酸反应，合成了八个糖酯类化合物，其中六个未见文献报道，所有产物的结构经ＩＲ，１ＨＮＭＲ，元素分析等所证实，并初步测定了其抗肿瘤活性．
A series of compounds:methyl 1-O-arylcarbonyl-2, 3, 4-tri-O-acetyl-β-D-glucopyranuronate 3a￣3c,5a￣5e had been synthesized by the reaction of furancarboxylic acid 1a￣ 1c,substitutied benzoic acid 4a￣4d,pyrimidin carboxylic acid 4e and methyl 2, 3, 4-tri-O-acetyl-1-bromo-ldeoxy-α -D-glupyranuronate 2 under phase transfer catalysis. 3a￣3c and 5a￣5c are new compounds. Their structures were confirmed by IR,1HNMRand elementary analysis. Preliminary results of the in vitro tests on HL-60 tumor cellsshowed that the inhibitory ratio of 3a was 50. 8%, 3b was 47. 0% and sc was 32. 5 %.
出处
《山东大学学报（自然科学版）》
CSCD
1996年第3期327-331,共5页
Journal of Shandong University(Natural Science Edition)
关键词
糖酯
合成
糖苷
葡萄糖醛酸甲酯
生物活性
furancarboxylic acid
PTC
1-ester of methyl glucopyranuronate
antitumor activity
