摘要
肿瘤坏死因子(TNF)和Okadaicacid(OA)能诱发人神经母细胞瘤SK细胞死亡,死亡细胞缩小变圆,细胞质凝聚,DNA断裂形成以200bP左右为单位的梯形分布,且上述过程可由蛋白质合成抑制剂亚胺环己酮(CHX)抑制,显示TNF和OA诱发的SK细胞死亡为细胞程序死亡.
TNF and OA can induce cell death in the human nurobiastoma SK cell line with the characteristic features of apoptosis. Cells are rounded and shrink;cytoplasm condenses; DNA is fragmented into a 200 bp ladder. Moreover,the above phenomenon can be partially inhibited by protein synthesis inhibitor cycloheximide.
出处
《厦门大学学报(自然科学版)》
CAS
CSCD
北大核心
1996年第4期597-599,共3页
Journal of Xiamen University:Natural Science
基金
国家自然科学基金