摘要
目的:系统性评价胺碘酮预防心脏手术后心房颤动(房颤)的效果。方法:通过中英文电子数据库及手工检索的方式,收集胺碘酮与安慰剂比较预防心脏手术后房颤效果的随机对照临床试验。运用Meta分析法进行统计。结果:14篇文献符合纳入排除标准,应用固定效应模型合并结果,RR为0．66(95％CI:0．58-0．76)。亚組分析显示,胺碘酮首次给药时间和给药方式对房颤的预防作用没有影响。敏感度分析证实了Meta分析结果的稳定性。结论:与安慰剂相比,胺碘酮可以有效地降低心脏手术后房颤的发生率。
Objective： To review whether prophylactic amiodarone has any preventive effects on the incidence of atrial fibrillation（AF） in patients undergoing cardiac surgery. Method： With the help of electronic databases and hand searches, prophylactic effects of post-operative atrial fibrillations with amiodarone compared with placebo were collected to perform some randomized controlled tests and then statistical combinations were conducted with the meta-analysis. Result： A fixed-effect model of meta-analysis was conducted and 15 identified studies were in accordance with the exclusive criterion. The combined relative risk （RR） was 0.66 （ 95% CI：0.58-0.75 ）. The subgroup analyses showed that the time of initial administration of amiodarone or the way of the administraions presented no effects on the postoperative atrial fibrillation. The stability of the result was approved by sensitivity analysis. Condusion： Compared with that of the placebo group, the result demonstrated the effectiveness of amiedarone in decreasing the risk of the atrial fibrillation after heart surgery.
出处
《药物流行病学杂志》
CAS
2006年第2期65-68,共4页
Chinese Journal of Pharmacoepidemiology
关键词
胺碘酮
心脏术后
房颤
META分析
Amiodarone
Cardiac post-operation
Atrial fibrillation
Meta-analysis
