摘要
目的了解临床酵母样真菌的感染类型、分布以及耐药情况,为临床诊断治疗提供合理的用药依据。方法采用常规方法进行真菌培养,用科玛嘉显色培养基联合法国生物梅里埃API 20C AUX鉴定条进行鉴定,药敏试验采用微量稀释法。结果864株酵母样真菌中,白色念珠菌619株(71.6%),其次为热带念珠菌116株(13.4%)和克柔念珠菌47株(5.4%),非白色念珠菌感染的比例逐年上升(21.5%)。其中,呼吸道标本酵母样真菌检出率最高,达79.7%,其次是消化道为8.8%,泌尿道为4.7%。科室分布依次为干部科、呼吸科、急诊内科、血液科等;白色念珠菌对两性霉素B、5氟-胞嘧啶高度敏感,达90%以上,对氟康唑和伊曲康唑的敏感性有所降低。结论酵母样真菌的检出率与患者基础疾病密切相关;对氟康唑等药物的敏感性有下降的趋势,未发现对4种药物同时耐药的菌株,提示在治疗中,药敏监测是非常必要的。
Objective To realize the type and distribution of fungi infection and drug resistance which will guide the diagnosis and therapy for clinical doctors. Methods A total of 864 strains of yeast-like fungi were identified with CHRO-Magar medium and API-20C AUX strips. Drug susceptibilities test of Candida was tested by mierodilution method. Results Among 864 strains,Candida albicans accounted for 619 strains （71.6%） ,C. tropicalis 116 strains（ 13.4% ） ,C. krusei 47 strains （5.4%）, the rate of non-Candida abicans infection presented a higher trend year by year（21.5% ）. The infection rate of yeast-like fungi from respiratory tract was the highest, accounted for 79.7%, digestive tract and urinary come second. The distribution of Dept. were Senioior cadres medicial, Dept. of respiratory medicine, Dept. of emeryeney medicine, Dept of hematology etc. The Candida albicans showed strong sensitivity to Amphotericine B and 5-Flueytosine, but to Flueonazole and Itraconazole were more weak than before. Conclusions The detectable rate of yeast-like fungi were intently related to the type of basic diseases; Susceptibilities to Flueonazole decreased, we did not detect any strain was resistnat to all four drugs synchronously. So we suggest that it was necessary to monitor antifungal susceptibility in treatment.
出处
《中国微生态学杂志》
CAS
CSCD
2006年第2期120-121,123,共3页
Chinese Journal of Microecology
关键词
酵母样真菌
感染
耐药性
Yeast-like Fungi
Infection
Resistance
