摘要
目的探讨血清基质金属蛋白酶(MMP)1、MMP-2与女性年龄、骨密度(BMD)及骨转换生化指标之间的关系。方法用ELISA测定591例20～80岁女性志愿者血清MMP1、MMP-2、血清骨碱性磷酸酶(BAP)、血清骨钙素(OC)和血清Ⅰ型胶原氨基末端肽(NTX),用DEXA测定腰椎1～4正位总体、股骨颈、Ward三角区、总髋部的BMD。结果(1)MMP-1、MMP-2与年龄呈正相关。(2)绝经后妇女MMP-2水平高于绝经前妇女(P<0.001)。(3)MMP-2与BMD呈负相关(P<0.05),但多元线性回归分析表明MMP-2不是BMD的预测因子。(4)MMP-2与血清BAP、OC、NTX正相关(P<0.01)。(5)绝经后骨质疏松症患者血清MMP-2水平高于年龄匹配的正常对照组、骨量减少组(P<0.01)。结论血清MMP-2与骨转换生化指标相关联。血清MMP-2水平升高可能为高骨转换过程(如绝经后骨质疏松症)中的一种伴随表现。
Objective To study the relationship between serum matrix metaUoproteinase （MMP） -1, MMP-2 and bone turnover markers, bone mineral density （BMD） in Chinese women aged 20 - 80 years. Methods Serum MMP-1, MMP-2, bone alkaline pbosphatase （BAP）, osteocalcin （OC） and cross-linked N-telopeptide of collagen type I （NTX） were measured using ELISA. BMD were measured using DEXA in 591 women. Results （1） MMP-1 and MMP-2 were positively correlated with age （both P 〈 0. 001 ）. （2）Level of MMP-2 in postmenopausal women was significantly higher than that in premenopausal women （P 〈 0. 001 ）. （3）Significant negative relationship was found between MMP-2 and BMD, but multiple linear stepwise regression analysis showed MMP-2 was not the determinant factor of BMD. （4） Positive correlation was found between MMP-2 and BAP, OC, NTX （ all P〈 0.001）. （5） Serum MMP-2 concentrations were significantly higher in postmenopausal osteeporofic women than in age-matched normal controls and osteepenic subjects. Conclusion Circulating MMP-2 and markers of bone turnover are related and they may increase with the increase in bone-turnover. The increase of serum MMP-2 appears possibly as a concomitant event in high bone turnover state such as postmenopausal osteoporosis.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2006年第4期306-309,共4页
Chinese Journal of Internal Medicine
基金
国家自然科学基金资助项目(30200322)
卫生部临床学科重点项目(20012738)
湖南省自然科学基金资助项目(03JJY1005)
