摘要
目的：研究单剂量肌肉注射甲磺酸齐拉西酮后药动学。方法：健康受试者10名肌肉注射甲磺酸齐拉西酮注射液20mg后不同时间取静脉血，高效液相色谱法测定其血药浓度，计算药动学参数，数据经3p97程序分析。结果：血药浓度-时间曲线为二室模型。药动学参数Cmax（866．32±482．88）ng／ml，tmax（0．57±0．23）h，t1／2ke（2．17±1．04）h，CL（17．0±9．00）ml／h，AUC0～12（1467．94±644．80）（ng·h）／ml，AUC0-∝（1603．48±722．47）（ng·h）／ml。结论：10名健康受试者肌肉注射甲磺酸齐拉西酮注射液20mg后药动学参数与国外文献报道结果基本一致。
OBJECTIVE： To study the pharmacokinetics of a single dose of intramuscularly injected ziprasidone mesylate in healthy volunteers. METHODS： A total of 10 healthy volunteers were received intramuscularly single dose of ziprasidone mesylate 20mg, venous blood samples were taken at different time after intramuscular injection, the concentrations of ziprasidone in serum were determined by HPLC, and the pharmacokinetic parameters were calculated with 3p97 program. RESULTS： The concentration- time curves of ziprasidone fitted to two compartment model. The pharmacokinetic parameters were stated as follows, Cmax was（866.32 ± 482.88） ng/ml; t max was（ 0.57 ± 0.23） h, t 1/2ke was（ 2.17 ± 1.04） h, CL was（ 17.0 ± 9.00） ml/h, A UC0 -12 was（1 467.94± 644.80） （ng · h）/ml and ACU0-∝ was（1 603.48± 722.47） （ng · h）/ml. CONCLUSIONS： The pharmacokinetics parameters in 10 healthy volunteers after intramuscular injection of 20mg ziprasidone mesylate are in llne with that reported in the literature.
出处
《中国药房》
CAS
CSCD
北大核心
2006年第7期516-517,共2页
China Pharmacy
