摘要
目的：建立以顸空气相色谱法测定夫西地酸中有机溶剂残留量的方法。方法：色谱柱为聚乙二醇20000 DM-WAX毛细管柱，柱温采取程序升温，检测器温度为250℃，载气为氦气，流速为7ml／min，分流比为1：1。结果：有机溶剂丙酮、甲醇、乙醇检测浓度线性范围分别为2．04～102．50μg／ml（r=0．9992）、2．00～99．98μg／ml（r=0．9995）、2．04～102．34μg／ml（r=0．9995），平均回收率分别为98．7％、99．2％、101．7％，RSD分别为2．11％、1．98％、2．01％。结论：本方法简便、结果准确，适用于夫西地酸中有机溶剂残留量的测定。
OBJECTIVE： To determine organic solvent residual volume in fusidic acid by headspace gas chromatography. METHODS：The determination was performed on polyoxyl 20 000 DM- WAX capillary, the column was subjected to temperature programming, the detector temperature was 250℃, the carrier gas was helium, the flow rate was 7ml/min and the split ratio was 1 ： 1.RESULTS： The linear detective concentration ranges of acetone, methanol and ethanol were 2.04 -102.50μg/ ml （ r = 0.9 992）, 2.00-99.98μg/ml（ r = 0.9 995） and 2.04-102.34μg/ml（ r = 0.9 995）, respectively, their average recovery rates were 98.7%, 99.2% and 101.7%, respectively with RSD at 2.11%, 1.98% and 2.01%, respectively.CONCLUSIONS： The method is simple,accurate,and suitable for the determination of organic solvent residual volume in fusidic acid.
出处
《中国药房》
CAS
CSCD
北大核心
2006年第7期535-536,共2页
China Pharmacy
关键词
夫西地酸
顶空气相色谱法
有机溶剂
残留量
Fusidic acid
Headspace gas chromatography
Organic solvent
Residual volume
