摘要
目的测定糖尿病患者外周血中CD62p、CD63、CD42a、CD4、CD8、CD3、CD16+56和微量元素锌(Zn)、铬(Cr)含量。方法应用流式细胞术测定CD62p、CD63、CD42a、CD4、CD8、CD3、CD16+56;用原子吸收光谱法测定Zn、Cr。结果糖尿病患者CD4、CD3、CD16+56、Zn、Cr水平显著低于正常对照组(P<0.01),而CD62p、CD63、CD42a、CD8水平则显著高于正常对照组(P<0.01)。结论糖尿病患者血小板膜糖蛋白(CD62p、CD63、CD42a)和免疫功能指标(CD4、CD8、CD3、CD16+56)及微量元素、锌(Zn)、铬(Cr)的含量在糖尿病病情观察、临床诊断治疗中可能起着一定的作用。
Objective To detect and compare the level of CD52p, CD53, CD42a, CD4, CD8, CD3, CD16 ＋ 56, Zn, Cr in the patients with diabetes and in the normal controls. Methods CD52p, CD53, CD42a, CD4, D8, CD3, CD16＋56cell concentration were measured in peripheral lood lymphocyte from patients with diabetes and normal groups by flow cytometry. Zn, Cr were measured by spectrometry. Results CD4, CD3, CD16＋56, CD4/CD8, Zn, Cr eoncemration among patients with diabetes were lower titan these of normal controls （ P 〈 0.01）, but CD52p, CI）53, CD42a, CD8 was highter than these of normal controls （ P 〈 0.01） . Conclusion The detection the levels of CI）52p, CI）53, CD42a, CD4, CD8, CD3, CD16 ＋ 56 and trace elements （Zn, Cr） may play an important in diagnosis treatment observation and patiosis of diabetes patients.
出处
《中国预防医学杂志》
CAS
2006年第1期11-13,共3页
Chinese Preventive Medicine
