期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血管内皮生长因子在脑缺血损伤的血管和神经保护作用 被引量：2

The Vascular and Neuroprotective Effect of Vascular Endothelial Growth Factor in Patients with Cerebral Ischemia Injury
下载PDF
导出
摘要 血管内皮生长因子是目前所知唯一作用于血管内皮的生长因子,在血管发生中处枢纽地位。它选择性地作用于内皮细胞、促进新生血管形成;它参与脑缺血损伤的病理生理过程。本文就VEGF血管和神经保护作用进展作一综述。 Vascular endothelial growth factor is only one endothelium specific growth factor that plays a pivotal role in angiogenesis, It acts selectively on endothelial cells to promote angiogenesis and takes part in pathophysiology process of cerebral ischemia injury, The article reviews the recent progress of VEGF about its vascular and neuroprotective effect.
作者 万赛英 黎杏群 顾卫 谭锋
机构地区 佛山市中医院神经内科 中南大学湘雅医院中西医结合研究所
出处 《医学综述》 2006年第7期401-404,共4页 Medical Recapitulate
基金 国家中医药管理局基金(2000-J-B-03)
关键词 血管内皮生长因子 脑缺血 血管再生 神经保护 Vascular endothelial growth factor Cerebral ischemia Angiogenesis Neuroprotection
分类号 R743 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献19

  • 1Hiratsuka S, Maru Y, Okada A, et al. Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1 ) in pathological angiogenesis[ J ]. Cancer Res, 2001,61 (3) :1207-1213.
  • 2Robinson CJ, Stringer SE. The splice variants of vascular endothelial growth factor (VEGF) and their receptors [ J ]. J Cell Sci, 2001,114(5) :853-865.
  • 3Giaccia A,Siim BG,Johnson RS. HIF-1 as a target for drug development[J]. Nat Rev Drug Discov, 2003,2(10) : 803-811.
  • 4Levy AP. Hypoxic regulation of VEGF mRNA stability by RNA-binding proteins[ J ]. Trends Cardiovasc Med, 1998,8(6) : 246-250.
  • 5Yancopoulos GD, Davis S, Gate NW, et al. Vascular-specific growth factors and blood vessel formation[J].Naure, 2000,407(14) : 242-247.
  • 6Zhang ZG, Zhang L,Tsang W, et al. Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia[ J ]. Cereb Blood Flow Metab, 2002, 22(4) :379-392.
  • 7Sun Y, Jin K, Xie L, et al. VEGF-indueed neuroprotoction, neuregenesis,and angiogenesis after focal cerebral ischemia[J]. J Clin Invest,2003,111(12) : 1843-1851.
  • 8Marti H.J, Bemaudin M, Bellail A. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia[ J] .Am J Pathol,2000,156(3) :965-976.
  • 9Krupinski J, Kaluza J, Kumar P, et al. Role of angiogenesis in patients with cerebral ischemie stroke[ J ]. Stroke, 1994,25 (9) : 1794-1798.
  • 10Hayashi T, Abe K,Itoyama Y. Reduction of ischemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia[J] .J Cereb Blood Flow Metab.1998,18(8) :887-895.

同被引文献19

  • 1万赛英,黎杏群,梁清华,智屹惠,罗云,张花先.脑溢安对缺氧大鼠脑微血管内皮细胞VEGF蛋白表达的影响[J].中南大学学报（医学版）,2005,30(2):153-156. 被引量：7
  • 2刘宝瑛,简奕婪,钟梅,余艳红,王前,张军.妊娠晚期糖尿病孕妇止凝血功能指标检测的临床意义[J].南方医科大学学报,2007,27(1):35-37. 被引量：14
  • 3李丽丹,冯玲.血管内皮生长因子(VEGF)与妊娠的研究进展[J].中国优生与遗传杂志,2007,15(2):3-4. 被引量：14
  • 4Jung K H, Chu K, Lee S T, et al. Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation [ J]. Brain Res, 2006, 16 ( 1073-1074 ) : 190- 201.
  • 5Wang Y, Gu Y, Zhang Y, et al. Evidence of endothelial dysfunction in preeclampsia: Decreased endothelial nitric oxide synthase expression is associated with increased cellpermeability in endothelial cells from preeclampsia[J].Am J Obstet Gynecol,2004, 190(3) :817-824.
  • 6Yao RQ, Zhang L, Wang W, et al. Cornel iridoid glycoside promotes neurogenesis and angiogenesis and improves neurological function after focal cerebral ischemia in rats. Brain Res Bull, 2009,79 : 69-76.
  • 7Ding YH,Li J,Zhou Y. Cerebral angiogenesis and expression of angiogenic factors in aging rats after exercise. Curr Neurovasc Res,2006,3:15-23.
  • 8Ling L, Hou Q, Xing S, et al. Exogenous kallikrein enhances neurogenesis and angiogenesis in the subventricular zone and the peri-infarction region and improves neurological function after focal cortical infarction in hypertensive rats. Brain Res, 2008,24,1206 : 89-97.
  • 9Hayashi T, Abe K, Itoyama Y. Reduction of ischemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia. J cereb Blood flow metab, 1998,18:887-895.
  • 10London NR, Whitehead KJ, Li DY. Endogenous endothelial cell signaling systems maintain vascular stability. Angiogenesis, 2009,27 : 1.

引证文献2

二级引证文献7

医学综述
2006年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部