C.elegans as a model system for Parkinson disease 被引量：2

C.elegans as a model system for Parkinson disease

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摘要 Parkinson disease(PD) is characterized by the selective loss of dopaminergic neurons in the substantia nigra. Although investigation in mammalian animal models of PD has enhanced our understanding of PD, the complexity of the mammalian nervous system and our inability to visualize DA neurons in vivo restricts the advances in elucidating the molecular mechanisms of PD. Conservation between C. elegans and mammals in genomic, biosynthetic and metabolic pathways as well as the advantages of observing DA neurons morphology in vivo and the ease of transgenic and genetic manipulation make C. elegans an excellent model organism for PD. Parkinson disease （PD） is characterized by the selective loss of dopaminergic neurons in the substantia nigra.Although investigation in mammalian animal models of PD has enhanced our understanding of PD, the complexity of the mammalian nervous system and our inability to visualize DA neurons in vivo restricts the advances in elucidating the molecular mechanisms of PD. Conservation between C. elegans and mammals in genomic, biosynthetic and metabolic pathways as well as the advantages of observing DA neurons morphology in vivo and the ease of transgenic and genetic manipulation make C. elegans an excellent model organism for PD.

作者 Pu PU,Wei-Dong LE State Key Laboratory of Medical Genomics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine Institute of Health Sciences,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences-Shanghai Jiao Tong University School of Medicine,Shanghai 200031,China

出处《Neuroscience Bulletin》 SCIE CAS CSCD 2006年第2期124-128,共5页 神经科学通报（英文版）

关键词 caenorhabditis elegans（ C. elegans） Parkinson disease dopaminergic neuron 帕金森疾病神经系统多巴胺能临床

分类号 R742.5 [医药卫生—神经病学与精神病学]

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