摘要
计算机仿真是对心脏电生理进行理论研究的重要手段。本文用R ush和L arsen提出的算法求解心室肌细胞Luo-R udy模型中的常微分方程(ODE's)。用算子分裂法结合自适应时间步长算法求解心肌组织传导模型中的偏微分方程(PDE's)。采用这些方法我们完成了单个心室肌细胞模型和两维组织模型的计算机仿真程序。用这些软件研究了激发螺旋波的方法。从两维计算机模拟中获得的数据可进一步用于等电位线、螺旋波尖端的轨迹及伪心电图(pseudo-ECG)的研究。
Computer simulation is one of the powerful protocols to study electrophysiology theoretically. In this paper,the algorithm of Rush and Larsen was used to solve the ordinary differential equations （ODE＇s） in the Luo-Rudy models of mammalian ventricular cell. The operator splitting and adaptive time step methods were used to solve the partial differential equations （PDE＇s） in cardiac tissue conduction models. Using these methods we accomplished the simulation programs of single ventricular cell model and two-dimensional （2-D） tissue model. The methods of initiating spiral waves were studied with this software. The data obtained from 2-D simulation can be used for further study on isopotential contour lines, spiral wave tip trajectories, and pseudo-ECG.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2006年第2期419-423,共5页
Journal of Biomedical Engineering
基金
国家自然科学基金资助课题(30570733)
关键词
心脏电生理
计算机仿真
螺旋波
Cardiac electrophysiology Computer simulation Spiral wave
