摘要
目的评价新辅助化疗对乳腺癌腋窝淋巴结的影响。方法45例Ⅱ、Ⅲ期乳腺癌接受新辅助化疗后手术（新辅助化疗联合手术组），根据体检、B超及钼靶像计数腋窝淋巴结总数和阳性、阴性淋巴结数，与未行新辅助化疗直接手术治疗的79例乳腺癌（直接手术组）比较，观察腋窝淋巴结的变化。结果新辅助化疗联合手术组检出腋窝总淋巴结和阳性淋巴结为（16．9±5.9）枚和（2．5±2．2）枚，显著低于直接手术组的（20．8±8．0）枚和（3．9±3．0）枚（t=-2．856，P=0．005；t=2．790，P=0．006），2组阴性淋巴结分别为（14．4±5．4）枚和（16．7±7．0）枚，无统计学差异（t=-1．904，P=0．055）。新辅助化疗联合手术组40例随访6—19个月，平均10个月；直接手术组67例随访7—21个月，平均12个月，2组各有4例复发。结论乳腺癌经新辅助化疗后行腋窝淋巴结清扫所检出的淋巴结总数和阳性淋巴结数减少。
Objective To evaluate effects of neoadjuvant chemotherapy on axillary lymph node status in patients with breast cancer. Methods A total of 45 patients with stage Ⅱ or Ⅲ breast cancer treated with neoadjuvant chemotherapy followed by surgery （ Combination Group） were compared with 79 patients with breast cancer treated with initial surgery only （ Surgery Group） in respect of axillary lymph node status, including the total number of the lymph nodes and the number of positive and negative lymph nodes, according to findings of physical examination, B-uhrasonography, and molybdenum target radiography. Results The total number of the lymph nodes and the number of positive lymph nodes were significantly less in the Combination Group （ 16.9 ± 5.9 and 2.5 ± 2.2 ） than in the Surgery Group （20.8±8.0 and 3.9 ±3.0） （t= -2.856, P=0.005; t=2.790, P=0.006）, whereas the number of negative lymph nodes were 14.4 ± 5.4 and 16.7 ± 7.0 in the Combination Group and the Surgery Group, respectively, without statistical significance （t = - 1. 904, P = 0. 055 ）. Four patients were found loco-regional relapse in each group during follow-up checkups for 6 ± 19 months （mean, 10 months） in 40 patients in the Combination Group and 7 -21 months （mean, 12 months） in 67 patients in the Surgery Group. Conclusions Total and positive axillary lymph nodes retrieved after axillary lymph node dissection decrease in number after neoadjuvant chemotherapy.
出处
《中国微创外科杂志》
CSCD
2006年第4期272-274,共3页
Chinese Journal of Minimally Invasive Surgery
关键词
新辅助化疗
乳腺癌
腋窝淋巴结
Neoadjuvant chemotherapy
Breast cancer
Axillary lymph node
