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重症肌无力合并胸腺瘤的临床特点 被引量:8

Clinical characteristics of MG patients with thymoma
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摘要 目的为了探讨重症肌无力(MG)合并胸腺瘤的临床特点和手术治疗后的效果。方法自1983年3月 ̄2004年12月我们对76例MG病人实施了胸腺瘤切除术,术后69例病人出院后被随访6个月 ̄20年。结果28例病人的胸腺瘤为良性,48例病人的胸腺瘤为恶性。术后有35.5%的病人出现了MG危象,主要见于Ⅱb和Ⅲ型病例。术后在院死亡率为6.6%。随访结果为31.9%病人的MG症状得以治愈;23.2%病人的MG症状得以改善;5.8%病人症状同术前;36.2%病人死亡于该病。结论MG合并胸腺瘤病例特点为病情较重,发展快,术前术后易出现MG危象,围手术期死亡率较高,预后欠佳。术前药物治疗和胸腺瘤切除的早期行气管切开对于治疗重症病例非常重要。这也是预防治疗MG危象及降低围手术期死亡率有效的方法。 [Objective] To study the clinical characteristics of MG patients with thymoma and the effects after operation, [Methods] Thymoma excision were performed on 76 patients with MG from March 1983 to December 2004. Sixty-nine patients after operation were followed up for 6 months to 20 years after being discharged from hospital. [Results] There were 28 patients with benign thymomas and 48 patients with malignant thymomas. MG crises were seen in 35.5% of patients postoperatively, most in type Ⅱ and Ⅲ. The mortality of in-patients after operation was 6.6%. The MG symptoms were relieved in 31.9%, improved in 23.2% and unchanged in 5.8% of patients. 36.2% of patients died of the disease. [Conclusions] The characteristics of MG with thymoma are: more severe condition of the patient, rapid advance, and more MG crises before and after operation. The perioperative mortality from MG with thymoma is higher and its prognosis is unfavourable. It is very important to treat severe cases of MG with thymoma by medication and tracheostomy with thymoma excision at the early stage after the operation. This is an effective method to prevent and treat MG crises as well to lower the pefioperative mortality.
出处 《中国现代医学杂志》 CAS CSCD 北大核心 2006年第7期1055-1057,共3页 China Journal of Modern Medicine
关键词 重症肌无力(MG) 胸腺瘤 MG危象 thymoma myasthenia gravis(MG) MG crises
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参考文献8

  • 1YOUNGER DS,RAKSADAWAN N.Medical therapies in myasthenia gravis[J].Chest Surg Clin N,2001,11(2):329-336.
  • 2RICHMAN DP,AGIUS MA.Treatment of autoimmune myasthenia gravis[J].Neurology,2004,63(6):1138-1139.
  • 3MONDEN Y,NAKAHARA K,FUJII Y,et al.Myasthenia gravis in elderly patients[J].Ann Thorac Surg,1985,39(5):433-436.
  • 4BRIL V,KOJIC J,DHANANI A.The long-term clinical outcome of myasthenia gravis in patients with thymoma[J].Neurology,1998,51(4):1198-1200.
  • 5PHILLIPS LH.The epidemiology of myasthenia gravis Semin Neurol,2004,(1):17-20.
  • 6李罗清,孙圣刚,曹学兵,徐金枝,杨明山,常丽英,殷小平.糖皮质激素对重症肌无力患者白细胞介素-6和乙酰胆碱受体抗体的影响(英文)[J].中国现代医学杂志,2004,14(19):42-45. 被引量:4
  • 7LI ZJ,CUI YS,ZHANG ZH,et al.Analysis of thymoma excision in patients with myasthenia gravis[J].Chin Med J,1996,109(12):946-948.
  • 8MANUEL LC,JOSE PB,ELOI EB,et al.Clinical and pathologic predictors of outcome in thymoma-associated myasthenia gravis[J].Ann Thorac Surg,2003,76(5):1643-1649.

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