摘要
目的探讨老年慢性阻塞性肺病(COPD)患者医院肺炎的常见病原菌类型及对常用抗菌药物的耐药情况。方法收集老年COPD医院肺炎的晨痰或气管切开处深部分泌物进行细菌培养和菌株鉴定,用微量稀释法药敏试验检测16种抗菌药物MIC90。结果分离出病原菌131株,其中革兰阴性杆菌84株(64.1%),铜绿假单胞菌居首位;酵母样真菌41株(31.3%);革兰阳性需氧球菌6株(4.6%)。多种革兰阴性杆菌对大多数抗菌药物的耐药率达30%以上,对亚胺培南的耐药率最低(0～11.1%),但在铜绿假单胞菌中已检出一定比例的中介菌株;对含酶抑制剂抗生素的耐药率低于不含酶抑制剂者。结论革兰阴性杆菌为老年COPD医院肺炎的主要病原菌,以铜绿假单胞菌为首位,对常用抗菌药物耐药率高。
[Objective] To study the bacteria type and drug resistance of pathogens for NP in elderly patients with COPD. [Methods] Sputa or tracheal exudation of NP in elderly patients with COPD were collected to isolate bacteria; The minimum inhibitory concentrations 90（MIC90） of 16 kinds of antibiotic was determined by microdilution method. [Results] 131 strains of bacteria were isolated among those, G^- bacillus were 84 strains （64.1%）, pseudomonas aeruginosa was premier; Fungus were 41 strains （31.3%）; G^＋ coccus were 6 strains （4.6%）. The resistant rate to most antibiotic of G^- bacillus was more than 30%, but to imipenem was only 0-11%, some inter mediate bacteria strains have been detected in pseudomonas aeruginosa and its resistant rate to antibiotics with restrainable enzyme was lower than that without restrainable enzyme. [Conclusion] G^- bacillus was main etiologic agent of NP in elderly patients with COPD; pseudomonas aeruginosa was premier and its resistant rate to antibiotics was high.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2006年第7期1083-1085,共3页
China Journal of Modern Medicine
