急性冠状动脉综合征患者血清基质金属蛋白酶-2与C-反应蛋白水平被引量：14

Approach of clinical significance of serum C-respective protein and matrix metalloproteinases-2 levels in acute coronary syndrome patients

原文传递

导出

摘要目的:在血清学水平上探讨C反应蛋白(CRP)、基质金属蛋白酶2(MMP2)与冠状动脉粥样硬化斑块破裂的关系,评价CRP、MMP2水平作为粥样硬化斑块破裂的血清学指标的意义。方法:分别利用酶联免疫吸附法及散射比浊法对40例急性冠状动脉综合征(ACS)组、40例稳定型心绞痛(SAP)组、40例非冠心病者(正常对照组)外周血血清CRP、MMP2水平进行测定。结果:ACS组、SAP组血清CRP、MMP2水平明显高于正常对照组,差异具有统计学意义(P<0.01),ACS组血清CRP、MMP2水平明显高于SAP组,差异具有统计学意义(P<0.01);经相关性检验血清CRP和MMP2水平呈明显正相关(P<0.01)。结论:血清CRP、MMP2水平可反映斑块稳定性,可作为检测斑块破裂的血清学指标。 Objective：To investigate the relationship between serum levels of C-respective protein （CRP）and matrix metalloproteinases-2 （MMP-2） and coronary atherosclerotic plaque rupture and its significance as serum target of plaque rupture. Method：The levels of CRP and MMP-2 in peripleral serum of 40 acute coronary syndrome （ACS） patients, stable angina pectoris（SAP） patients and 40 without coronary heart disease patients as control were measured, respectively by enzyme-llnked immunoassay（ELISA） and scatter rateturbidity. Result： The serum levels of CRP and MMP-2 in ACS group, SAP group were higher than that in without coronary heart disease group. The levels of CRP and MMP-2 in ACS group were higher than that in SAP group. There was a positive correlation between the levels of CRP and MMP-2. Conclusion： Elevation of serum level of CRP and MMP-2 are related with unstable plaque. It can be used as a serum target to judge plaque rupture.

作者丁巍魏渝娟万德中左云慧张浩禄秀秀

机构地区包头医学院在读研究生宁波大学附属第三医院急诊科包头医学院附属第三医院心内科

出处《临床心血管病杂志》 CAS CSCD 北大核心 2006年第4期217-219,共3页 Journal of Clinical Cardiology

关键词急性冠状动脉综合征基质金属蛋白酶-2 C-反应蛋白 Acute coronary syndrome C-respect protein ,Metalloproteinases-2

分类号 R541.4 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献12

1FUSTER V, ADIMON L, BADLMON J, et al. The pathogenisis of coronary artery disease and the acutecoronary syndromes [J]. N Eng J Med, 1992,326:242-250.
2TORZEWSI J, TORZEWSKI M, BOWYER D F, et al. C-reactive Protein frequently colocalizes with the terminal complement complex in the intima of early atherosclerotic lesions of human coronary arteries[J].Arterioacler Thromb Vasc Biol, 1998, 18: 1386-1392.
3HOFFMEISTER H M, EHLERS R, BUTTTTCHER E,et al. Comparison of C-reactive Protein and terminal complement complex in Patients with unstable angina Pectoris versus stable angina pectoris [J]. Am J Cardiol,2002,89:909- 912.
4RIDKER P M ,CUSHMAN M ,STEMPFER M J, et al. Infammation aspirin and the risk of cardoivascular diseases in apparently healthy men [J]. N Engl J Med, 1997,336 :973-979.
5葛智平,陈晓春.C反应蛋白与不同类型冠心病相关性的临床研究[J].临床心血管病杂志,2005,21(2):78-80. 被引量：37
6MORISHIGE K, SHIMOKAWA H, MATSUMOTO Y, et al. Overexpression of matrixmetalloproteinase-9 promotes intravaseular thrombus formation in porcine coronary arteries in vivo [J]. Cardiovase Res, 2003,57:572-85.
7BROWN D L, HIBBS M S, KEARNEY M, et al. Identifieation of 92-kD gelatinase in human coronary atheroselerotie lesions. Association of active enzyme synthesis with unstable angina [J]. Circulation,1995,91 :2125-2131.
8SHAH P K, FALK E, BADIMON J J, et al. Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture [J]. Circulation,1995,92:1565- 1569.
9KAI H, IKEDA H, YASUKAWA H, et al. Peripheral blood levels of matrix metalloproteases-2 and-9 are elevated in parients with acute coronary syndromes[J]. J Am Coll Cardiol, 1998,32 : 368- 372.
10HOJO Y, IKEDA U, UENO S, et al. Expression of matrix metalloproteinases in patients with acute myocardial infarction [J]. Jpn Circ J, 2001,65:71 - 75.

二级参考文献8

1Liuzzo G, Biasucci L M, Gallimore J R, et al. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med, 1994, 331: 417-424.
2Ridker P M, Hennekens C H, Buring J E, et al. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med, 2000, 342: 836-843.
3Kuller L H, Tracy R P, Shaten J, et al. Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. Am J Epidemiol, 1996,144: 537-547.
4Iftihar J K, Willian D E, Robert S S. Vulnerable plaque: Pathobiology and clinical implication. Ann Inter Med, 1998, 129:1050-1060.
5Prediman K, Shah M D. Plaque disruption and thrombosis: Potential role of inflammation and infection. Cardiol Rev, 2000, 8: 32-39.
6Haught W H, Mansour M, Rothlein R, et al. Alteration on circulating intercellular adhesion molexule-1 and L-selectin: further evidence for chronic inflammation in ischemic heart disease. Am Heart J, 1996, 132: 1-6.
7Lagrand W K, Niessen H W. C-reactive protein colocaliaes with complement in human hearts during acute myocardial infarction. Circulation, 1997, 95: 97-103.
8裴志勇,杨庭树,杜洛山,盖鲁粤,王禹.不稳定型心绞痛炎性因子与冠状动脉病变的对比研究[J].临床心血管病杂志,2002,18(7):308-310. 被引量：27