摘要
目的了解深圳市结核病的耐药状况及其动态变化。方法采用“比例浓度法”对每例菌株进行H、R、E、S四种药物的敏感试验。结果1999年至2005年进行耐药监测共3761例,原发性耐药率27.7%(958/3459),继发性耐药率41.1%(124/302);原发性耐多药率4.2%(146/3459),继发性耐多药率16.2%(49/302)。四种抗结核药的耐药频率顺序由高至低依次为S、H、R、E。结论积极推行肺结核病归口管治和实施DOTS策略,结核病疫情明显下降,结核病耐药率呈下降趋势。
Objective To explore the drug resistant situation of mycobacterium tuberculosis and to appraise the effect of tuberculosis controls plan. Methods Each example strain of four drugs H, R, E and S, was tested on sensitivity using proportion density law. Results The drug resistant of mycobacterium tuberculosis of 3761 examples were monitored from 1999 to 2005. The primary drug resistant rate was 27.7% （958/3459） and the repeated drug resistant rate was 41.1% （124/302）. The primary multi-drug resistant rate was 4.2% （146/3459）, and the repeated smulti-drug resistant rate was 16.2% （49/302）, The drug resistant of rates were ranked from high to low as S, H, R and E. Conclusion The rate of drug resistant of mycobacterium tuberculosis declines under the DOTS in Shenzhen.
出处
《临床肺科杂志》
2006年第3期304-305,共2页
Journal of Clinical Pulmonary Medicine
关键词
结核病
分析杆菌
监测
耐药性
tuberculosis, myeobaeterium, monitor, drug resistant
