摘要
目的研究老年住院患者院内肺部感染（NP）病原菌特点及其耐药性。方法对2000年12月～2002年12月本院内科住院3d以上的201例患者的NP发生率、病原菌特点及药物敏感试验结果进行回顾性分析。结果201例患者的NP发生率为25．9％（52／201），NP发生率与住院时间呈正相关（P〈0．01）。分离培养出病原菌133株，G^-菌占69．9％，G^＋菌占22．5％，真菌占7．5％。共有51株细菌产超广谱8内酰胺酶（ESBL），占细菌总数的41．5％。ESBL的产生率与住院时间呈正相关（P〈O．05）。大部分细菌呈现出多重耐药性。结论老年住院患者NP的发生率较高。病原菌以G^-菌为主，铜绿假单孢菌居首位，金黄色葡萄球菌居第二。大部分病原菌呈现多重耐药性，细菌产ESBL是其原因之一。
Objective To investigate the causative organisms and the drug--resistance of nosocomial pulmonary infection（NP）in department of internal medicine. Methods The morbidity of NP in 201 patients who had stayed in department of internal for 3 days or more during the period from december 2000 to december 2002 was analyzed retrospectively. The pathogens spectrum and their resistance profiles were analyzed also. Results Among the 201 patients, 52 of themodeVeloped nosocomial pulmonary infection once at least and the morbidity was 25.9%. The hospitalization time was directly related to the morbidity（P〈0.01）. In 133 strains of pathogens from 38 of 52 NP patients, the percentage of G^- bacteria,G^＋ bacteria,and fungi were 69.9% ,22.5% ,and 7. 5% respectively. Fifty--one of 123 strains of bacteria produced ESBL. The percentage was 41. 50%. But there was no statistically significant difference between the two percentages to produce ESBL. Most of the bacteria were multiple-resistant to the tested antimicrobial. Conclusion The morbidity of NP was relatively high in senile patient, G-bacteria was the dominant causative pathogens. Among all the pathogens, the pseudomonas aeruginosa was the most major one, followed by staphylococcus aureus. Most of the pathogens were multiple-resistant. ESBL production is one of the major causes.
出处
《江西医学院学报》
2006年第2期110-112,共3页
Acta Academiae Medicinae Jiangxi
