摘要
目的以等效价剂量芬太尼为对照,探讨舒芬太尼用于术后静脉自控镇痛的优越性。方法60例择期全麻下开腹手术患者,ASAI-Ⅱ,随机分为舒芬太尼(SF)组和芬太尼(F)组,每组30例。SF组术后镇痛以舒芬太尼3μg/kg,F组术后镇痛以芬太尼0.024mg/kg,均稀释至100ml,负荷量3ml,背景剂量2ml/h,自控追加剂量2ml/次,锁时15min。观察病人术后4h、12h、24h、40h疼痛评分、镇静评分和舒适程度评分、脉搏氧饱和度、PCA有效按压情况,以及恶心、呕吐的发生情况。结果术后4h、12h、24h舒芬太尼组的疼痛评分明显低于芬太尼组(P<0.05)。术后4h、12h的镇静评分、舒适评分舒芬太尼组高于芬太尼组。术后4h、12h、24h时点间舒芬太尼组的按压次数明显少于芬太尼组。SPO2在两组间无明显差别。术后40h内舒芬太尼组恶心、呕吐发生率明显低于芬太尼组(SF:5/30,F:12/30;P<0.05)。结论舒芬太尼是一较好的术后静脉镇痛药物,较芬太尼有着较强的镇痛、镇静作用,患者舒适程度较好,副作用少。
Objective To investigate the effect of sufentanil in the postoperative patient controlled intravenous analgesia （PClA）eomparison with equipotent doses of fentanyl. Methods 60 patients, ASAⅠ-Ⅱ ,scheduled for abdominal surgery under general anesthesia, were randomly assigned into two groups（n=30 per group）： Sufentanil（SF） and Fentanyl（F）.Patients in group SF reeevied sufentanil as postoperative analgesia. The dose of sufentanil was 3μg/kg and diluted with saline water for 100ml. The PCIA setting： loading dose 3 ml, bolus of 2 ml with lock time 15 minutes and background dose 2ml/h. Fentanyl 0.024mg/kg was a substitue for sufentanil in group F. Scores of analgesia, sedation and comfort were evaluated,and recorded the SPO2, times of PCA key pressed , nausea and vomiting at 4h,12h,24h and 40h postoperatively. Results The scores of analgesia in group SF were lower significantly than that in group F at 4h,12h,24h postoperatively. And the scores of sedation and comfort in SF were higher markedly than that in group F at 4h,12h after surgery. The incidence of nausea and vomiting were lower in group SF. Conclusion Sufentanil is better for postoperative patient controlled intravenous analgesia compare with fentanyl.
出处
《江西医药》
CAS
2006年第4期198-199,共2页
Jiangxi Medical Journal
关键词
舒芬太尼
芬太尼
静脉自控镇痛
sufentanil
fentanyl
patient-controlled intravenous analgesia
