摘要
目的探讨代谢综合征(MS)患者胰岛素抵抗(IR)与血清白介素10(IL-10)水平的关系。方法 MS患者及年龄相匹配的正常对照组各18例。以高胰岛素-正常血糖钳夹技术检测葡萄糖代谢率(M值),评价IR程度:采用酶联免疫吸附法检测血清IL-10水平,用Pearson相关分析法分析血清IL-10水平与M值的相关性。结果 MS组M值显著低于对照组[(5．76±1．81)mg／kg·min vs (8．39±1．25)mg／kg·mim,P<0．05];MS组血清IL-10水平显著低于对照组[1．3(0．8／3．1) pg／ml vs 2．4(1．1／4．5)pg/ml,P<0．05];Pearson相关分析法显示血清IL-10水平与M值正相关(P<0．05)。结论 MS患者血清IL-10水平降低,可能与IR的发生有关。
Objective To investigate the relationship between serum interleukin-10 （IL-10） level and insulin resistance （IR） in patients with metabolic syndrome （MS）. Methods Eighteen MS subjects and 18 age-matched normal subjects were enrolled. IR was evaluated by hyperinsulinemic-euglycemic clamp technique and serum IL-10 level measured by ELISA. Pearson＇s correlation analysis was used to investigate the relationship between serum IL-10 level and IR. Results Serum IL-10 levels were significantly higher in patients with MS than in the controls [1.3 （0.8/3.1） pg/ml vs 2.4 （1.1/4.5） pg/ml, P〈0.05], and glucose metabolic rate （M value） derived from hyperinsulinemic-euglycemic clamp technique was lower in MS subj ects than in controls [（5.76±1.81） mg/kg.min vs （8.39±1.25） mg/kg.min],P〈0.05]. Serum IL-10 levels showed a positive correlation with M value （P〈0.05）. Conclusion Patients with MS have greater IR and lower serum IL-10 levels than normal subjects, and lowered IL-10 levels might be involved in the pathogenesis of IR in MS.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2006年第4期428-430,共3页
Journal of Southern Medical University
基金
教育部博士点基金(002000001)
卫生部基金(000099009)
关键词
代谢综合症
白介素-10
胰岛素抵抗
葡萄糖钳夹技术
metabolic syndrome
intedeukin-10
insulin resistance
hyperinsulinemic-euglycemic clamp
