摘要
目的观察子宫内膜异位症伴不孕患者腹腔镜手术后加用米非司酮或达那唑治疗子宫内膜异位症的临床疗效、副作用及停药后对妊娠率、复发率的影响。方法98例经腹腔镜手术确诊为子宫内膜异位症的患者,随机分为2组。米非司酮组48例,给予米非司酮10mg口服,每日1次;达那唑组50例,400mg/d,分2￣4次口服,均连续用药3个月。观察并比较两组临床症状、体征、用药后的副作用及停药后2年内症状复发率和妊娠率等变化。结果两组症状、体征缓解率相似,均较治疗前明显改善;米非司酮组体重增加、肝功能损害、阴道异常出血等副反应发生率明显低于达那唑组;停药后米非司酮组月经平均恢复时间较达那唑组短;2年内两组症状和体征复发情况相似,不孕患者的累积妊娠率差异无显著性。结论腹腔镜手术后加用小剂量米非司酮和达那唑均可有效控制子宫内膜异位症患者症状,提高不孕患者的妊娠机会,而米非司酮在减少副反应方面优于达那唑,是腹腔镜术后联合用药的理想选择,值得临床推广应用。
[Objective] To observe the therapeutic and side effects of mifepristone and danazol on endometrinsis patients with infertility after laparoscopic operation and the influences on pregnancy and relapse rates after withdrawal. [Methods] 98 cases of endometriosis patients with infertility confirmed by laparoscopy were randomly divided into 2 groups. The mifepristone group （n =48） were given mifepristone 10 mg/d and the danazol group were given danazol 400 mg/d for 3 months. The clinical symptoms, signs and the side effects as well as the pregnancy and relapse rates after withdrawal were observed and compared. [Results] The clinical symptoms and signs were significandy improved during treatment in beth groups. Side effects including body weight gain, liver function impairment and vaginal irregular bleeding were occurred less in mifepristone group than in those of danazol group. The average time of menstruous restoration was earlier in mifepristone group than in that of danazol group. There were no significant differences in pregnancy and relapse rates after withdrawal within two years between two groups. [Conclusion] Either mifepristone or danazol could control the symptoms of endometriosis patients and improve the pregnancy rate of those complicated with infertility. However mifepristone has the advantage of fewer side effects than dannazol and promise to be an ideal drug for endometriosis patients after laparoscopic operation.
出处
《中国内镜杂志》
CSCD
北大核心
2006年第4期434-436,共3页
China Journal of Endoscopy
