摘要
目的：研究高碘性甲状腺肿形成的机制并寻求合适的硒干预剂量。方法：140只Balb／c小鼠分为7组：正常组、高碘组（饮水含碘3000μg／L）和5个补硒组（饮水含碘3000μg／L，硒分别为0．1、0．2、0．3、0．4、0．5mg／L），共喂养16w。放射免疫法测定甲状腺激素水平，测定血浆、肝脏、肾脏和甲状腺组织谷胱甘肽过氧化物酶（GSH-Px）和超氧化物歧化酶（SOD）活性，丙二醛（MDA）水平。结果：高碘组GSH-Px、SOD活性下降，MDA含量升高，而经饮水补充0．2～0．3mg／L硒组各项指标与正常组无显著性差异。结论：高碘会导致小鼠抗氧化能力下降，而经饮水补充0．2～0．3mg／L硒是有效的干预剂量。
Objective： To study the mechanism of goiter resulted from excess of iodine and seek suitable selenium intervention dosage. Method： One hundred and forty Balb/c mice were divided into seven groups： the normal control group, the high iodine group （drinking the water containing iodine 3 000μg/L） and five selenium groups （drinking the water containing iodine 3 000μg/L and selenium 0.1, 0.2, 0.3, 0.4, 0.5mg/L）. The GSH-Px, SOD activities and the concentration of MDA in plasma, liver and kidney were determined. Result： The GSH-Px、SOD activities of high-iodine group decreased significantly and MDA increased significantly compared with normal control group. There was no difference between normal control group and the groups drinking the water containing 0.2-0.3 mg/L selenium. Conclusion： Iodine excess results in oxidative damage and 0.2-0.3 mg/L selenium is an effective intervention dosage.
出处
《营养学报》
CAS
CSCD
北大核心
2006年第2期128-131,共4页
Acta Nutrimenta Sinica
基金
国家自然科学基金(No.30230330)
