摘要
目的观察血清血管内皮生长因子(VEGF)、细胞间粘附分子-1(ICAM-1)在肝细胞癌(HCC)手术前后的变化,探讨其在肝癌诊断中的价值。方法应用酶联免疫分析法测定56例HCC手术患者VEGF及ICAM-1水平,并与60例正常对照组进行比较。结果肝癌患者血清中VEGFI、CAM-1含量明显高于正常对照组(P<0.001),HCC患者手术后血清中VEGFI、CAM-1含量明显下降(P<0.01)。结论血清ICAM-1及VEGF水平的升高与HCC病情的发展,预后判断及疗效观察关系密切。
Objective To study the post-operative change of serum vascular endothelial growth factors（VEGF） and intercellular adhesion molecule-1（ICAM-1） in hepatocellular carcinoma（HCC） and the value in the diagnosis of liver cancer. Methods 56 patients with surgical operation of HCC and 60 healthy people were divided into treatment group and control group. Their Serum levels of VEGF and ICAM-1-were determined by ELISA ,and were compared with control group . Results Level of VEGF and sICAM-1 in treatment group was higher than the control group,P〈0. 001 . level of VEGF and sICAM-1 dropped obviously after operation in control group. P〈0.01. Conclusion The increase of serum ICAM-1 and VEGF are related with the development and prognosis and clinical effect of HCC.
出处
《右江医学》
2006年第2期126-127,共2页
Chinese Youjiang Medical Journal
关键词
肝癌
血管内皮生长因子
细胞间粘附分子-1
酶联免疫吸附法
liver cancer
vascular endothelial growth factors （VEGF）
intercellular adhesion molecule-1（ICAM-1）
enzyme linked immunosorbent assay（ELISA）
