摘要
目的探讨肾功能正常或代偿期的IgA肾病中医证型与肾小球免疫物质沉积之间的关系。方法36例。肾功能正常及代偿期的IgA肾病患者进行中医辨证分型，肾小球系膜区免疫物沉积度定量评分，分析中医证型与肾小球系膜区免疫物沉积类型及沉积度定量评分间的关系。结果肾功能正常及代偿期的IgA肾病患者，肺（脾）肾气虚型以3种免疫复合物沉积为主，气阴两虚型以4种免疫复合物沉积为主；在肾小球系膜区IgA沉积度定量评分比较中，肺（脾）肾气虚型IgA沉积度定量评分高于气阴两虚型，两证型之间有统计学差异（P〈0．05）；两证型在IgM、IgG、C3沉积度定量评分比较中无统计学差异（P〉0．05）。结论肺（脾）肾气虚型向气阴两虚型转变过程中，肾小球系膜区免疫复合物沉积种类增加；肺（脾）肾气虚型肾小球系膜区IgA沉积度高于气阴两虚型。
Objective To discuss the relationship between traditional Chinese medicine （TCM） Syndrome type and immune deposition in IgA nephropathy with normal or compensatory renal function, Method 36 IgA nephropathy patients were assigned to different TCM Syndrome type. Immunoglobulin type and quantitative scoring of immunoglobulin deposit in glomerular mesangial were recorded, then discuss the relationship between them were investigated. Results 3 kinds of immunity compound mainly deposits in lung（spleen）-kidney Qi-deficiency type, 4 kinds of immune compound mainly deposited in Qi-Yin deficiency type of IgA nephropathy with normal to compensatory renal function; comparing the quantitative score of immunoglobulin deposits in glomerular mesangial, the score of IgA deposit in lung（spleen）-kidney Qi-deficiency type was higher than that in Qi-Yin deficiency type. There was significant difference （P〈0. 05） in IgA deposit score, but no significance difference （P〉 0. 05 ） in IgM, IgG and C3 deposit degrees between Qi-Yin deficiency type and lung（spleen）-kidney Qi-deficiency type. Conclusions In IgA nephropathy with normal to compensatory renal function, the kinds of immune compound deposits in glomerular mesangial are more when TCM Syndrome type thansform from lung（spleen）-kidney Qi-deficiency type to Qi-Yin deficiency type, the score of immune IgA deposit is higher in lung（spleen）-kidney Qi-deficiency type than in Qi-Yin deficiency type.
出处
《临床肾脏病杂志》
2006年第2期83-85,共3页
Journal Of Clinical Nephrology
关键词
IGA肾病
中医证型
免疫沉积物
IgA nephropathy
Syndromes type of TCM
Immune deposition
