摘要
目的:探讨肿瘤标志物CA125、CA199、CEA、N SE对肺癌的诊断价值,探讨四项标志物在肺癌不同病理类型及治疗前后的表达情况。方法:采用电化学发光法对75例肺癌患者和60例肺良性病变患者血清中CA125、CA199、CEA、N SE的含量进行检测,比较。结果:①肺癌组患者的CA125(115.83±113.21)、CEA(12.43±11.72)、N SE(17.81±8.13)均显著高于肺良性病变组,差异有显著性意义(P<0.01)。CA199(12.1±8.8)在两组的表达水平比较无显著性差异(P>0.05)。②肿瘤标志物CEA在肺癌不同病理类型中总体比较有显著性差异,其中腺癌的CEA水平(20.65±13.88)显著高于其它类型(P<0.01),小细胞肺癌的N SE水平高于其它病理类型(P<0.01)。③标志物联合检测的敏感度性73.33%(55/75)明显高于单项检测(CEA 45.33%,CA12553.33%,N SE 36.00%)。结论:①肿瘤标志物CA125、CEA、N SE在肺部良、恶性病变的鉴别诊断中有意义。CA199不宜作为肺癌的肿瘤标志物临床应用。②肿瘤标志物CA125、CEA、N SE在不同病理分型的肺癌中的表达有差别。③联合检测肿瘤标志物CA125、CEA、N SE的灵敏性明显提高。
Objective： To study the diagnosis value of CA125, CA199, CEA and NES in lung cancer. Methods： The serum levels of CA125, CA199, CEA and NES were assayed and compared between the lung cancer group （75 cases） and the benign lung diseases group （60 cases） by electrochemiluminesence immunoassay. Results： 1. The serum levels of CA125, CEA and NES in the lung cancer group were 115.83 ±113. 21,12. 43±11.7,and 17.81±8. 13,respectively ,which were higher than those in the benign disease group, with no statistic difference in CA199（12.1±8.8）between the two groups. 2. Generally, there were statistic differences in CEA level in different pathology types of lung cancer. Adenocarcinoma had a much higher CEA level （20. 65±13. 88） compared with other pathology types. Small cell lung cancer had a higher NSE level. 3. The sensitivity of combined tumor marker measurment was 73. 33%（55/75 ）,much higher than a single marker measurement（CEA 45.33%, CAa25 53.33%, NSE 36. 00%）. Conclusion： ① The serum CA125, CEA and NES are of great value in differentiation diagnosis of lung benign from malignant disease, with CA199inadvisable as a tumor marker.②The combined measurement of serum CA125, CEA and NES can improve diagnostic sensitivity and specificity of lung cancer. ③The combined measurement of serum CA125, CEA and NES in the patients with pleural effusion is advocated ,which can improve the differentiation diagnostic sensitivity.
出处
《黑龙江医药科学》
2006年第2期23-24,共2页
Heilongjiang Medicine and Pharmacy
