摘要
目的:探讨氟西汀治疗老年抑郁症的疗效及安全性。方法:56例老年抑郁症患者随机分为两组:A组和B组,每组各28例。A组采用氟西汀治疗,B组采用阿米替林治疗,两组疗程均为6周。两组疗效评定采用汉密顿抑郁量表(HAMD),两组副反应评定采用副反应量表(TESS)。结果:A组治疗后第2、4、6周末HAMD评分与B组比较,无显著性差异(P>0.05),A组治疗后第2、4、6周末TESS评分明显低于B组(P<0.05)。A组总有效率为78.57%,B组总有效率为71.43%,两组比较,无显著性差异(P>0.05)。结论:氟西汀可作为治疗老年抑郁症的首选药物。
Objective： To explore the clinical effect and safety of fluoxetine in elderly depression. Methods： Fifty-six patients with elderly depression were double-blind assigned to fluoxetine group and amitriptyline group for 6 weeks. Efficacy was assessed with the Hamilton rating scale for depression（HAMD）and tolerability was assessed from rating scale for adverse effect. Results ： Fluoxetine possessed similar efficacy to amitriptyline, the fluoxetine and amitriptyline time of the effect was similar, but the side effects of fluoxetine were slighter than those of amitriptyline. Conclusion： Fluoxetine is effective and safety treatment of elderly depression,and maybe the first choice of drugs for elderly depression.
出处
《实用临床医学（江西）》
CAS
2006年第4期31-32,共2页
Practical Clinical Medicine
