摘要
目的评价胃肠道来源肺转移瘤CT导向下125I粒子植入治疗的短期疗效。方法20例胃肠道来源肺转移瘤患者,肺内病灶5个以下,总计病灶数56个,平均每例2.8个病灶,病灶平均直径2.1cm(0.5～3cm)。其中单肺转移13例,双肺7例。原发病灶均有病理诊断,肺转移均经CT或MRI检查后临床诊断。利用计算机三维立体定向治疗计划系统(TPS)计算布源,在CT引导下将125I粒子植入肺转移病灶内。观察治疗后2个月病灶变化。结果20例56个病灶,完全缓解(CR)32个;部分缓解(PR)19个;无变化(NC)5个。总有效率91.1%。2个月内无死亡病例。发生气胸2例,咯血痰2例,胸腔出血1例,均经对症治疗后好转。结论胃肠道来源肺转移瘤,肺内病灶5个以下,最大直径不超过3cm,CT导向下125I粒子植入治疗,创伤小,并发症发生率低,近期效果好。
Objective To investigate the short term effect of CT guided radioactive seed 125^Ⅰ implantation in treating pulmonary metastases from gastrointestinal tumor. Methods 20 patients （male 13, female 7, the age range of 25 to 73, mean age 49 ± 24） with pulmonary metastases from gastrointestinal tumor accepting CT guided radioactive seed 125^Ⅰ implantation were enrolled in this study. Among these patients, no more than 5 pulmonary metastases lesions occurred in any one case ,diameters of all lesions were from 0.5 to 3.0 cm with. average 2.8 lesions per case,and the mean diameter of pulmonary metastases was 2.1 cm.13 cases presented pulmonary metastases only unilaterally, and 7 others were found bilaterally.All primary tumors were confirmed by pathology, and pulmonary metastases were identified by CT or MRI and confirmed through pathology. Under CT guidance,125^Ⅰ seeds were implanted into pulmonary metastases according to CT based computerized treatment planning in radio-oncology of the treatment planning system （TPS）.All cases were observed two months after the treament. Results Among 56 pulmonary metastases in 20 patients, 32 obtained CR, 19 PR, 5 NC. The responsive rate was 91.1%. During follow up, no morality occurred, but with complications of pneumothorax in 2 cases,bloody sputum in 2 cases,hemothorax in 1 case. Conclusions CT guided radioactive seed 125^Ⅰimplantation procedure possesses satisfied clinical effects in treating pulmonary metastases from gastrointestinal tumor with minimal damage and few complications ,especially in these patients with no more than 5 pulmonary metastases, and less than 3.0 cm in diameter.
出处
《介入放射学杂志》
CSCD
2006年第4期235-237,共3页
Journal of Interventional Radiology
