摘要
目的测定盐酸洛美沙星葡萄糖注射液中的5-羟甲基糠醛(5-HMF)。方法采用HPLC法,用 HYPERSILBDS C18色谱柱,以柠檬酸(pH 4．0):乙腈(80:20)为流动相,检测波长为287 nm。结果 5-HMF在 0．25-10．0μg/mL范围内线性关系良好(r=0．999 9),平均回收率为99．2％(RSD=0．62％)。结论采用 HPLC测定盐酸洛美沙星葡萄糖注射液中的5-HMF,方法简便,准确可靠。
Objective To determine 5-HMF in lomefloxacin hydrochloride and glucose injection. Methods Hypersilbds C18 column was used, with the mobile phase of citric acid（pH 4.0）： aeetonitrile（80 ： 20）. The detection wavelength was 287 nm. Results The calibration curves of 5-hydroxyrnethylfurfural was linear in range of 0.25 -- 10.0μg/ mL. The average recovery was 99.2 % （RSD = 0.62 % ）. Conclusion The method is specific and reliable.
出处
《实用药物与临床》
CAS
2006年第2期80-81,92,共3页
Practical Pharmacy and Clinical Remedies
